Diethylstilbestrol is a Medicine belongs to Estrogen group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,

  ►   Brandname : Stilphostrol

  ►  Strength : Tablet with 50  mg, Injection with 0.25  gm, Pessary with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12, Martindale    Page : 2301   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, parenteral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 760   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Malignant neoplasms of the breast Oral 10 20 mg Tablet Dose: For palliative treatment: Given daily
2 Carcinoma of the prostate Oral 1 3 mg Tablet Dose: Given daily

Ref :-  Book : Martindale    Page : 2301   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, fluid retention, arterial thrombosis, venous thrombosis, impotence, Gynaecomastia, withdrawal bleeding, hypercalcaemia, bone pain,
Ref :-   Book : Martindale    Page : 2300   Edition : 37,

►  Drug Interaction : Drug interaction of Diethylstilbestrol is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : pregnancy, hepatic impairment, renal impairment, cardiovascular disease,
Ref :-   Book : Martindale    Page : 2300   Edition : 37,
  ►  Mechanism of Action :   Diethylstilbestrol is a synthetic nonsteroidal oestrogen. Plasma estrogens in the blood and interstitial fluid are bound to SHBG, from which they dissociate to enter the cell and bind to their receptor. Two genes code for two estrogen receptor isoforms, α and β, which are members of the superfamily of steroid, sterol, retinoic acid, and thyroid receptors. Binding of the hormone to its receptor alters its conformation and releases it from the stabilizing proteins (predominantly Hsp90). The receptor-hormone complex forms homodimers that bind to a specific sequence of nucleotides called estrogen response elements (EREs) in the promoters of various genes and regulate their transcription. Ref: Martindale pg no 2301 ed 37.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 718-719   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal,
Ref :-   Book : Martindale    Page : 2301   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA