Dimenhydrinate is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 627   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Gravol,Draminate,Calm-X,Dimetabs,Dinate,Dramamine,Dramanate,Dymenate,Hydrate,Triptone,Dimen,Reisegold,Reisetabletten,Rodavan S,RubieMen,Superpep,Vertigo- Vomex,Vomacur,Vomex A,Vertizac

  ►  Strength : Chewable tablets with 50  mg, Liquid with 12.5/5  mL, Tablet with 50  mg, Liquid with 12.5 mg/4  mL, Liquid with 15.62 mg/5  mL, Injection with 50  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, rectal,
Reference :-   Book : Martindale    Page : 627   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Motion sickness Oral 50 100 mg Tablet t.i.d/q.i.d Dose: First dose should be given at least 30 minutes before travelling.
2 Motion sickness IM 50 mg Injection Dose: a concentration of 5% being used
3 Motion sickness slow i.v 50 mg Injection Dose: a concentration of 0.5% being used (usually over 2 minutes).

Ref :-  Book : Martindale    Page : 627   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nausea 2 Year 6 Year Oral 12.5 25 mg
2 Vomiting 2 Year 6 Year Oral 12.5 25 mg
3 Nausea 6 Year 12 Year Oral 25 50 mg
4 Vomiting 6 Year 12 Year Oral 25 50 mg
5 Motion sickness IM 1.25 mg/kg Injection q.i.d.
6 Motion sickness

Ref :- Book : Martindale    Page : 627   Edition : 37,
►  Side Effect : Sedation, dry mouth, pupillary dilation, Dizziness, dry eyes, urinary retention,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,

►  Drug Interaction : Drug interaction of Dimenhydrinate is with CNS depressant, Alcohol, Barbiturates , Hypnotics, opioid analgesics, Antipsychotics, antidepressants, Tricyclic antidepressants, Monoamine Oxidase Inhibitor, Anxiolytic sedatives,  Atropine ,
Ref :-   Book : Martindale    Page : 613, 627   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedative interactions apply to a lesser extent with the non-sedating antihistamines; they do not appear to potentiate the effects of alcohol, but it should be avoided in excess. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs).,
Ref :-   Book : Martindale    Page : 613, 627   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with Another pathway,

  ►  Pathway with its reference as follows :-
  • antiemetic effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA