Dimercaprol is a Medicine belongs to Chelator Antidote group whose information about Brand can be referenced from   Book : Martindale    Page : 1585   Edition : 37,

  ►   Brandname : Zorex

  ►  Strength : Injection with 100  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1025   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM,
Reference :-   Book : Martindale    Page : 1584   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe acute poisoning IM 3 5 mg/kg Injection
2 Severe acute poisoning IM 400 800 mg Injection Dose: Given on the first day of treatment, 200 to 400 mg on the second and third days, and 100 to 200 mg on the fourth and subsequent days, all in divided doses

Ref :-  Book : Martindale    Page : 1584   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute poisoning 1 Month 18 Year IM 2.5 3 mg/kg Injection

Ref :- Book : Martindale    Page : 1585   Edition : 37,
►  Side Effect : hypertension, tachycardia, nausea, vomiting, headache, burning sensation of the lips, mouth, throat, eyes, lachrymation, Salivation, tingling of the extremities, sensation of constriction in the throat, chest, muscle pain, muscle spasm, rhinorrhoea, conjunctivitis, sweating, Restlessness, abdominal pain, Transient reductions in the leucocyte count, sterile abscesses, fever, pain at the injection site,
Ref :-   Book : Martindale    Page : 1584   Edition : 37,

►  Drug Interaction : Drug interaction of Dimercaprol is with NA

  ►    Mechanism of Drug Drug Interaction :  Iron supplements should not be given during dimercaprol therapy as toxic dimercaprol-metal complexes are formed.,
Ref :-   Book : Martindale    Page : 1584   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment, renal insufficiency, hypertension, It should not be used in the treatment of poisoning due to cadmium, iron, or selenium as the dimercaprol-metal complexes formed are more toxic than the metals themselves,
Ref :-   Book : Martindale    Page : 1584   Edition : 37,
  ►  Mechanism of Action :   The sulfhydryl groups on dimercaprol compete with endogenous sulfhydryl groups on proteins such as enzymes to combine with these metal chelation by dimercaprol therefore prevents or reverses any inhibition of the sulfhydryl enzymes by the metal and the dimercaprol-metal complex formed is readily excreted by the kidney. Since the complex may dissociate, particularly at acid pH, or be oxidised, the aim of treatment is to provide an excess of dimercaprol in body fluids until the excretion of the metal is complete.,
Ref :-   Book : Martindale    Page : 1584   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- steamed charcoal with Another pathway,

  ►  Pathway with its reference as follows :-
  • Having antidote effect --- (: Khah, A. (2016). Activated Charcoal: Preparation, characterization and Applications : A review article. International Journal Of Chemtech Research, 1(4). )

  •   ►  URL -- http://sphinxsai.com/ctvol4/ct_pdf_vol_4/ct=10%20%20%28859--864%29.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B6 with Decrease in Nutrient Level, IRON with Decrease in Nutrient Level, COPPER with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ZINC with Increase urinary mineral excretion ., COPPER with Increase urinary mineral excretion .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 1584   Edition : 37,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1584   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   30 minutes,    Max value :-   60 minutes,
    Ref :-   Book : Martindale    Page : 1584   Edition : 37,