Dipyridamole is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1396   Edition : 37,

  ►   Brandname : Persantin,Aggrenox

  ►  Strength : Tablet with 25  mg, Tablet with 50  mg, Tablet with 75  mg, Tablet (Extended Release Tablets) with 200  mg, Oral Suspension with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12, Martindale    Page : 1396   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1396   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of thromboembolism Oral 300 600 mg Dose: Given daily in divided doses before meals
2 Stroke Oral 200 mg b.d. Dose: Given as a modified-release preparation, alone or with aspirin.
3 Transient ischemic attacks Oral 200 mg b.d. Dose: Given as a modified-release preparation, alone or with aspirin.

Ref :-  Book : Martindale    Page : 1396   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Prophylaxis of thromboembolism 1 Month 12 Year Oral 2.5 mg/kg b.d.
2 Kawasaki disease 1 Month 12 Year Oral 1 mg/kg t.i.d.
3 Prophylaxis of thromboembolism 12 Year 18 Year Oral 2.5 mg/kg b.d.

Ref :- Book : Martindale    Page : 1396   Edition : 37,
►  Side Effect : gastrointestinal disturbance, nausea, vomiting, diarrhea, headache, Dizziness, faintness, hypotension, facial flushing, Skin rashes, hypersensitivity reactions, chest pain, cardiac arrhythmia, worsening of symptoms of angina,
Ref :-   Book : Martindale    Page : 1396   Edition : 37,

►  Drug Interaction : Drug interaction of Dipyridamole is with Antacid ,  Fludarabine, Adenosine ,
Ref :-   Book : Martindale    Page : 1396   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Dipyridamole may enhance the actions of oral anticoagulants due to its antiplatelet effect. It inhibits the reuptake of adenosine and may enhance its effects; the dose of adenosine must be reduced if both drugs are given. Dipyridamole may also inhibit the uptake of fludarabine and may reduce its efficacy. The absorption of dipyridamole may be reduced by drugs such as antacids that increase gastric pH.,
Ref :-   Book : Martindale    Page : 1396   Edition : 37,


►  Contraindication : Dipyridamole should be used with caution in patients with hypotension, unstable angina, aortic stenosis, recent myocardial infarction, heart failure, or coagulation disorders, Intravenous dipyridamole should not be given to patients with these conditions or to those with arrhythmias, conduction disorders, asthma, or a history of bronchospasm,
Ref :-   Book : Martindale    Page : 1396   Edition : 37,
  ►  Mechanism of Action :   Inhibit platelet Camp degradation and thereby decrease platelet aggregability.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 395   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- GARLIC with It enhances the benefical action of dipridamoie ., CAFFEINE with Caffiene interact with dipyridamole ,

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1396   Edition : 37,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   12 hours,
    Ref :-   Book : Martindale    Page : 1396   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   75 minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1396   Edition : 37,