Disopyramide is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1399   Edition : 37,

  ►   Brandname : Norpace,Rythmodan

  ►  Strength : Capsules with 100  mg, Capsules with 150  mg, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12, Martindale    Page : 1398   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1398   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Supraventricular and ventricular arrhythmias Oral 300 800 mg Capsule Dose: Given daily in divided doses
2 Supraventricular and ventricular arrhythmias slow i.v 2 mg/kg Injection Dose: maximum of 150 mg, at a rate not exceeding 30 mg/minute; this is followed by 200 mg orally immediately on completion of the injection and every 8 hours for 24 hours.
3 Supraventricular and ventricular arrhythmias IV infusion 400 micrograms/kg/hour Injection Dose: maximum of 800 mg daily, Patients receiving disopyramide intravenously or in high oral doses should be monitored by ECG
4 Supraventricular and ventricular arrhythmias IV infusion 20 30 mg/hour Injection Dose: maximum of 800 mg daily, Patients receiving disopyramide intravenously or in high oral doses should be monitored by ECG

Ref :-  Book : Martindale    Page : 1398   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Supraventricular and ventricular arrhythmias 1Year Oral 10 30 mg/kg Capsule
2 Supraventricular and ventricular arrhythmias 1 Year 4 Year Oral 10 20 mg/kg Capsule
3 Supraventricular and ventricular arrhythmias 4 Year 12 Year Oral 10 15 mg/kg Capsule
4 Supraventricular and ventricular arrhythmias 12 Year 18 Year Oral 6 15 mg/kg Capsule

Ref :- Book : Martindale    Page : 1398   Edition : 37,
►  Side Effect : dry mouth, Blurred Vision, urinary hesitancy, Impotence, constipation, urinary retention, gastrointestinal effects, nausea, bloating, abdominal pain, Skin rashes, hypoglycemia, Dizziness, fatigue, insomnia, Depression, Psychosis, cholestatic jaundice, thrombocytopenia, agranulocytosis, prolongation of the QT interval, ventricular tachycardia, fibrillation, heart block, conduction disturbances, elevated liver enzymes, worsen arrhythmias, heart failure, hypotension,
Ref :-   Book : Martindale    Page : 1397   Edition : 37,

►  Drug Interaction : Drug interaction of Disopyramide is with Beta Blockers , , , , ,  NA

  ►    Mechanism of Drug Drug Interaction :  Disopyramide should be used cautiously with drugs that have negative inotropic effects or that affect conduction, including beta blockers and other class I antiarrhythmics; it prolongs the QT interval and should not be given with other arrhythmogenic drugs. Disopyramide is metabolised by the cytochrome P450 isoenzyme CYP3A4 and interactions may occur with inhibitors or inducers of this enzyme and with other drugs metabolised by CYP3A4. Use of disopyramide with other antimuscarinic drugs produces enhanced antimuscarinic effects.,
Ref :-   Book : Martindale    Page : 1398   Edition : 37,


►  Contraindication : complete heart block (unless the patient has a pacemaker), cardiogenic shock, conduction disorders or uncompensated heart failure, renal impairment, hepatic impairment, heart failure, hypoglycemia, Owing to its antimuscarinic properties, disopyramide should be avoided in patients with glaucoma or a tendency to urinary retention, as in benign prostatic hyperplasia, and also in patients with myasthenia gravis because of the risk of precipitating a myasthenic crisis,
Ref :-   Book : Martindale    Page : 1397,1398   Edition : 37,
  ►  Mechanism of Action :   Moderate block of voltage –gated Na channels and block of K channels in ventricular myocytes (decreases phase O upstroke velocity and prolong depolarization) and SA nodal cells (shifts threshold to more positive potentials and decreases slope of phase 4 depolarization) ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 418   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Squill with Another pathway,

  ►  Pathway with its reference as follows :-
  • Glucoscillarene A and Scillarenescillieyanoside have Anti arrhythemic effect --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- POTASSIUM with Large amount of high-potassium foods at the same time if kidney is not functioning well .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1398   Edition : 37,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   10 hours,
    Ref :-   Book : Martindale    Page : 1398   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1398   Edition : 37,