Dobutamine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1400   Edition : 37,

  ►   Brandname : Dobutrex

  ►  Strength : Intravenous infusion with 12.5  mg/ml, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 224   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1400   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cardiac stress testing IV infusion 5 micrograms/kg/min Injection Dose: A solution containing 1 mg/mL is given via an infusion pump in a dose of 5 micrograms/kg per minute for 8 minutes. It is given by intravenous infusion as a dilute solution (0.25 to 5 mg/mL), in glucose 5% or sodium chloride 0.9%; other fluids may also be suitable and the manufacturers’ guidelines should be consulted.
2 Acute heart failure IV infusion 2.5 10 micrograms/kg/min Injection Dose: according to the patient’s heart rate, blood pressure, cardiac output, and urine output. It is given by intravenous infusion as a dilute solution (0.25 to 5 mg/mL), in glucose 5% or sodium chloride 0.9%; other fluids may also be suitable and the manufacturers’ guidelines should be consulted.

Ref :-  Book : Martindale    Page : 1400   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cardiovascular disorders continuous i.v infusion 5 micrograms/kg/min Injection

Ref :- Book : Martindale    Page : 1400   Edition : 37,
►  Side Effect : angina, chest pain, palpitations, anxiety, fear, Restlessness, insomnia, Confusion, irritability, headache, dysphonia, weakness, anorexia, nausea, vomiting, Dose-related increases in blood pressure, Dose-related increases in heart rate, ectopic beats, psychotic states, ,
Ref :-   Book : Martindale    Page : 1399,1544   Edition : 37,

►  Drug Interaction : Drug interaction of Dobutamine is with NA

  ►    Mechanism of Drug Drug Interaction :  Most interactions with dobutamine are due to its direct beta1 agonist effects on the heart, but use with beta blockers may allow its alpha- and beta2-agonist effects to become apparent. Dobutamine has a positive inotropic action caused by the isomer with predominantly β-receptor activity. It has relatively greater inotropic than chronotropic effect compared with isoproterenol. Ref 4 pg no 141 ed 12.,
Ref :-   Book : Martindale    Page : 1400   Edition : 37,


►  Contraindication : Marked obstruction of cardiac ejection, such as idiopathic hypertrophic subaortic stenosis, Used with caution in patients with acute myocardial infarction, and in cardiogenic shock complicated by severe hypotension. Hypovolaemia should be corrected before treatment,
Ref :-   Book : Martindale    Page : 1399,1400   Edition : 37,
  ►  Mechanism of Action :   Increase cAMP by activating G protein- coupled adrenergic receptors; acting at cardiac β1 –adrenergic receptors, agonist have positive inotropic, chronotopic, and lusitropic effects. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 435   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Sesame seed with same pathway,

  ►  Pathway with its reference as follows :-
  • beta-adrenergic blockers . --- ( Houston, M. (2013). Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part III. J Clin Hypertens, 15(12), 931-937. )

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/jch.12211/pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1400   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1400   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA