Docetaxel is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 779   Edition : 37,

  ►   Brandname : Taxotere,Docetax,Daxotel

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 779   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 779   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prostate cancer IV 75 mg/m2 Injection Dose: Given once every 3 weeks, with prednisone or prednisolone 5 mg orally twice daily given continuously.
2 Gastric adenocarcinoma IV infusion 75 mg/m2 Injection Dosse: given before cisplatin and fluorouracil; treatment is repeated every 3 weeks.
3 Neck cancer IV infusion 75 mg/m2 Injection Dose; Given before cisplatin and fluorouracil; treatment is given every 3 weeks for 3 cycles, followed by chemoradiotherapy, or for 4 cycles when followed by radiotherapy alone.
4 Head cancer IV infusion 75 mg/m2 Injection Dose; Given before cisplatin and fluorouracil; treatment is given every 3 weeks for 3 cycles, followed by chemoradiotherapy, or for 4 cycles when followed by radiotherapy alone.
5 Non-small cell lung cancer IV infusion 75 mg/m2 Injection Dose: Given for both first-line combination therapy and monotherapy after failure of previous chemotherapy for once every 3 weeks.
6 Breast cancer IV infusion 60 100 mg/m2 Injection Dose: Given after failure of previous chemotherapy for once every 3 weeks
7 Breast cancer IV infusion 75 mg/m2 Injection Dose: once every 3 weeks is given in combination therapy with doxorubicin, or capecitabine, or when used as adjuvant therapy with doxorubicin and cyclophosphamide.

Ref :-  Book : Martindale    Page : 779   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : neutropenia, fluid retention, ascites, pleural effusion, pericardial effusion, weight gain, hypersensitivity reactions, asthenia, fatigue,
Ref :-   Book : Martindale    Page : 778   Edition : 37,

►  Drug Interaction : Drug interaction of Docetaxel is with ,  Digoxin , Warfarin , Phenytoin , Suxamethonium chloride,
Ref :-   Book : Martindale    Page : 698,778   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Because of their effects on the gastrointestinal mucosa antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 Antineoplastics have been reported to affect a number of drugs including: digoxin (reduced absorption) Warfarin (increased or decreased effect), phenytoin (increased or decreased effect), suxamethonium (prolonged effect), vaccines (decreased response),
Ref :-   Book : Martindale    Page : 698,778   Edition : 37,


►  Contraindication : hepatic impairment, Avoid in In patients hypersensitive to polysorbate 80,
Ref :-   Book : Martindale    Page : 778   Edition : 37,
  ►  Mechanism of Action :   Bind polymerized tubulin and inhibit microtubule depolymerization,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 698   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Pacitaxel with Another pathway, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti cancer --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 779   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   11 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 779   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA