Docusate sodium is a Medicine belongs to Laxative group whose information about Brand can be referenced from   Book : Martindale    Page : 1876   Edition : 37,

  ►   Brandname : Coloxyl,Rectalad,Waxsol,Clear Ear,Dioctyl,Docusol,DulcoEase,Colace,DS- S,DC Softgels,Dioctyn,Docusoft

  ►  Strength : Capsule with 50  Mg, Capsule with 100  mg, Capsule with 250  mg, Tablet with 20  mg, Tablet with 50  mg, Tablet with 60  Mg, Syrup with 150/15  mg/ml, Enema with   , Oral solution with   , Extended- release tablets with   , Ear Drop with 0.5  %, Ear Drop with 5  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12, Martindale    Page : 1876   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Martindale    Page : 1876   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Constipation Oral 50 300 mg Dose: Given daily in divided doses
2 Constipation rectal 120 mg Enema
3 Softening wax in the ear Topical 0.5 5 % Ear Drop
4 Adjunct in abdominal radiological procedures Oral 400 mg

Ref :-  Book : Martindale    Page : 1876   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chronic constipation 6 Month 2 Year Oral 12.5 mg t.i.d.
2 Chronic constipation 2 Year 12 Year Oral 12.5 25 mg t.i.d.
3 Adjunct in abdominal radiological procedures Oral 75 mg
4 Constipation 12 year and over Oral 50 mg
5 Constipation 12 year and over rectal 120 mg Enema

Ref :- Book : Martindale    Page : 1876   Edition : 37,
►  Side Effect : Anorectal pain, Anorectal bleeding, ,
Ref :-   Book : Martindale    Page : 1876   Edition : 37,

►  Drug Interaction : Drug interaction of Docusate sodium is with ,  Liquid paraffin , Aspirin,
Ref :-   Book : Martindale    Page : 1876   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Docusates may enhance the gastrointestinal uptake of other drugs, such as liquid paraffin (and the two should not be given together). Dosage of anthraquinone laxatives may need to be reduced if used with docusates. It has also been suggested that giving docusates with aspirin increases the incidence of adverse effects on the gastrointestinal mucosa,
Ref :-   Book : Martindale    Page : 1876   Edition : 37,


►  Contraindication : Hypersensitivity, pregnancy, It Should not be used when intestinal obstruction or undiagnosed abdominal symptoms are present; prolonged use should be avoided, It should not be given rectally to patients with haemorrhoids or anal fissures, It should not be used to soften ear wax when the ear is inflamed or the ear drum perforated,
Ref :-   Book : Martindale    Page : 1876   Edition : 37,
  ►  Mechanism of Action :   Docusate salts are anionic surfactants that lower the surface tension of the stool to allow mixing of aqueous and fatty substances, softening the stool and permitting easier defecation. However, these agents also stimulate intestinal fluid and electrolyte secretion (possibly by increasing mucosal cyclic AMP) and alter intestinal mucosal permeability.,
Ref :-   Book : Goodman    Page : 1333   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Phyllium with Another pathway, Phyllium with Another pathway, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • Effective in treatment of constipation . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Effective in treatment of constipation . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Effective in treatment of constipation . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Effective in treatment of constipation . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Angeer having soluble fiber pectin stimulate healthy bowel movement, laxative effect . --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level, POTASSIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary,
    Ref :-   Book : Martindale    Page : 1876   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA