Domperidone is a Medicine belongs to Antiemetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1879   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Domperi,Domperon,Domstal,Nautigo,Stopvom,Vomistop,Motilium,Vivadone,Esofine-DSR,Esokem D,Omez D,Pan D,Rabefit DSR,Rapeed D,Cyra-D,Derek D,Sompraz D,Sompraz D 40,Drego-D

  ►  Strength : Tablet with   , Suppository with   , Oral Suspension with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1878,1879   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal, IV,
Reference :-   Book : Martindale    Page : 1878   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Nausea Oral 10 20 mg t.i.d/q.i.d Dose: up to a maximum daily dose 80 mg.
2 Vomiting Oral 10 20 mg t.i.d/q.i.d Dose: up to a maximum daily dose 80 mg.
3 Nausea rectal 60 mg Suppository b.d.
4 Vomiting rectal 60 mg Suppository b.d.
5 Dyspepsia Oral 10 mg q.i.d. Dose: (the last dose to be taken at night) have been recommended; if necessary, an increase in the dose to 20 mg may be prescribed. An initial course of treatment should not normally exceed 2 to 4 weeks.

Ref :-  Book : Martindale    Page : 1878   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nausea Oral 250 500 micrograms/kg t.i.d/q.i.d
2 Vomiting Oral 250 500 micrograms/kg t.i.d/q.i.d
3 Nausea More than 15 kg rectal 30 mg b.d.
4 Vomiting More than 15 kg rectal 30 mg b.d.
5 Nausea 12 Year 35 kg or more Oral 10 20 mg t.i.d/q.i.d
6 Vomiting 12 Year 35 kg or more Oral 10 20 mg t.i.d/q.i.d
7 Vomiting 12 Year 35 kg or more rectal 60 mg Suppository b.d.
8 Nausea 12 Year 35 kg or more rectal 60 mg Suppository b.d.
9 Gastrointrestinal stasis Oral 100 300 mcg/kg
10 Gastrointrestinal stasis 1 Month 12 Year Oral 200 400 mcg/kg t.i.d/q.i.d
11 Gastrointrestinal stasis 12 year and over 10 20 mg t.i.d/q.i.d

Ref :- Book : Martindale    Page : 1878   Edition : 37,
Precaution :- If a Patient is using 'Domperidone' drug in  parkinsonism  disease, then Please containdicated .

Precaution :- If a Patient is using 'Domperidone' drug in  Hyperprolactinemia  disease, then Please contraindicated .

►  Side Effect : galactorrhoea, Gynaecomastia, reduced libido, Rashes, drowsiness, convulsion, arrhythmia, cardiac arrest, extrapyramidal reactions,
Ref :-   Book : Martindale    Page : 1878   Edition : 37,

►  Drug Interaction : Drug interaction of Domperidone is with Opoid analgesic , , ,  Bromocriptine , Ritonavir, Ketoconazole , Erythromycin ,
Ref :-   Book : Martindale    Page : 1878   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  As with other dopamine antagonists, there is a theoretical potential that domperidone may antagonise the hypoprolactinaemic effect of drugs such as bromocriptine. In addition, the prokinetic effects of domperidone may alter the absorption of some drugs. Opioid analgesics and antimuscarinics may antagonise the prokinetic effects of domperidone. Domperidone is metabolised via the cytochrome P450 isoenzyme CYP3A4; use with ketoconazole has been reported to produce a three fold increase in plasma concentrations of domperidone, and an associated slight prolongation in QT interval. Similar increases in domperidone concentrations might theoretically be seen with other potent inhibitors of CYP3A4 such as erythromycin or ritonavir, and such combinations may be best avoided. ,
Ref :-   Book : Martindale    Page : 1878   Edition : 37,


►  Contraindication : It should be used with great caution if given intravenously, because of the risk of arrhythmias, especially in patients predisposed to cardiac arrhythmias or hypokalaemia, It is not recommended for chronic use or for the routine prophylaxis of postoperative nausea and vomiting,
Ref :-   Book : Martindale    Page : 1878   Edition : 37,
  ►  Mechanism of Action :   Domperidone are dopamine D 2 –receptor antagonists. Within the gastrointestinal tract activation of dopamine receptors inhibits cholinergic smooth muscle stimulation; blockade of this effect is believed to be the primary prokinetic mechanism of action of these agents. It increases esophageal peristaltic amplitude, increase lower esophageal sphincter pressure, and enhance gastric emptying but have no effect on small intestine or colonic motility. Domperidone also block dopamine D 2 receptors in the chemoreceptor trigger zone of the medulla (area postrema), resulting in potent antinausea and antiemetic action.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1092   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with Another pathway,

  ►  Pathway with its reference as follows :-
  • It is useful to treat to nausea and vomiting --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1878   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   7.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1878   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   Oral: 30 minutes, Rectal: 1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1878   Edition : 37,