Donepezil is a Medicine belongs to Antidementia drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 395   Edition : 37,

  ►   Brandname : Donaz,Donecept,Aricept

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Tablet with 23  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 395   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Dementia in Alzheimer’s disease Oral 5 mg Tablet o.d. Dose: daily increased if necessary after 4 to 6 weeks to a maximum of 10 mg once daily; the dose should be taken just before bedtime.

Ref :-  Book : Martindale    Page : 395   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, anorexia, diarrhea, fatigue, Dizziness, abdominal pain, dyspepsia, Rashes, pruritus, headache, Somnolence, muscle cramp, insomnia, sweating, tremor, syncope, upper respiratory-tract infections, urinary-tract infections, Psychiatric disturbances, Depression, hallucinations, agitation, aggressive behaviour, Confusion, ,
Ref :-   Book : Martindale    Page : 395   Edition : 37,

►  Drug Interaction : Drug interaction of Donepezil is with Alcohol,  Ketoconazole , Itraconazole , Erythromycin , Fluoxetine , Quinidine , Rifampicin , Phenytoin , Carbamazapine , Zonisamide ,
Ref :-   Book : Martindale    Page : 395   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Hepatic metabolism of donepezil via the cytochrome P450 system has been demonstrated; plasma concentrations of donepezil may be raised by drugs that inhibit the isoenzyme CYP3A4 such as ketoconazole, itraconazole, and erythromycin, and by those that inhibit the isoenzyme CYP2D6 such as fluoxetine and quinidine. Conversely, plasma-donepezil concentrations may be reduced by enzyme inducers such as rifampicin, phenytoin, carbamazepine, and alcohol.,
Ref :-   Book : Martindale    Page : 395   Edition : 37,


►  Contraindication : Gastrointestinal obstruction, Urinary-Tract Obstruction, Bladder or Gastrointestinal surgery, Care is also required in patients with a history of asthma, obstructive pulmonary disease, Parkinson’s disease, or seizures, and in those, with, or at risk of developing, peptic ulcer disease, Patients with cardiovascular conduction disorders such as sick-sinus syndrome may be susceptible to the vagotonic effects of acetylcholinesterase inhibitors,
Ref :-   Book : Martindale    Page : 395   Edition : 37,
  ►  Mechanism of Action :   Inhibit acetylcholinesterase (AChE) by binding to the enzyme’s active site,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 129   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Valerian with Another pathway, Ficus Religiosa i.e. figs with same pathway, Beilschmieda i.e.dalzells walnut with same pathway, Skimmia laureola with same pathway, Esenbeckia leicarpa with same pathway, Corydalis cava with same pathway, Catharanthus roseus i.e. sadabahar with same pathway, Ervatamia hainanesis with same pathway, Tabernaemontana i. e. Chandni. with same pathway, Uncaria rhynchophylla with same pathwaysame pathway, Uncaria rhynchophylla with same pathwaysame pathway, Himatanthus lancifolius e.i.agoniada. with same pathwaysame pathway, Himatanthus lancifolius e.i.agoniada. with same pathwaysame pathway, Hippeastrum papilio with same pathway, Huperzia serrata with same pathway, Andrographis paniculata with same pathway, Bayleaf with same pathway, Sanguisorba minor with same pathway, Sage with same pathway, Apple mint with same pathway, Lemon balm with same pathway, Salsola oppositifolia with same pathway, Salsola tragus with same pathway, Crinum moorei e.i. lily with same pathway, Nerine undulata with same pathway, Scadoxus multiflorus i.e. lily with same pathway, Sprekelia formosissima with same pathway, Zephyranthes grandiflora with same pathway, Kaempfera parviflora with same pathway, Harpephyllum caffrum with same pathway, Ashwagandha with same pathway, Pistachios with same pathway, Spondias mombin with same pathway, Gotu Kola with same pathway, Black pepper with same pathway, Amla with same pathway,

  ►  Pathway with its reference as follows :-
  • Anti-anxiety activity --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )
  • Acetyl cholinesatrase inhibitor --- (Chandrashekher, S .B. "Phytopharmacology Of Ficus Religiosa". Pharmacogn 4.8 (2010): 195–199. Web. 9 Nov. 2016. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- ( Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • Act as cholistrase inhibitor. --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Bayleaf or tejpatta act as acetylcholistrase inhibitor . --- ( Ferreira, A. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal Of Ethnopharmacology, 108, 31-37. )
  • Sanguisorba minor act as acetylcholistrase inhibitor. --- ( Ferreira, A. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal Of Ethnopharmacology, 108, 31-37. )
  • Sage act as acetylcholistrase inhibitor. --- ( Ferreira, A. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal Of Ethnopharmacology, 108, 31-37. )
  • Apple mint act as acetylcholistrase inhibitor. --- ( Ferreira, A. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal Of Ethnopharmacology, 108, 31-37. )
  • Lemon balm act as acetycholistrase inhibitor. --- (Ferreira, A. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal Of Ethnopharmacology, 108, 31-37. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249921/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/, http://esa.ipb.pt/pdf/RefPlants_13.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 395   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   70 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 395   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 395   Edition : 37,