Dorzolamide is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 2007   Edition : 38,

  ►   Brandname : Dorzox,Dortas,Trusopt

  ►  Strength : Ophthalmic Solution with 2  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : ophthalmic,
Reference :-   Book : Martindale    Page : 2006   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Glaucoma ophthalmic 2 % Eye Drop t.i.d. Dose: Given twice-daily regimen is recommended when used with a beta blocker

Ref :-  Book : Martindale    Page : 2006   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : conjunctivitis, keratitis, burning or stinging, eyelid inflammation or irritation, Blurred Vision, headache, bitter taste, epistaxis, fatigue, nausea, Corneal oedema and irreversible corneal decompensation have been reported in patients with pre-existing chronic corneal defects and/or a history or intra-ocular surgery,
Ref :-   Book : Martindale    Page : 2007   Edition : 38,

►  Drug Interaction : Drug interaction of Dorzolamide is with Thiazide Diuretics , ,  Amphetamine , Ephedrine , Quinidine , Methenamine , Aspirin, Felbamate,
Ref :-   Book : Martindale    Page : 2002,2007   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  By rendering the urine alkaline Dorzolamide reduces the urinary excretion, and so may enhance the effects, of drugs such as amfetamines, ephedrine, and quinidine; conversely, urinary alkalinisation can reduce the effects of methenamine and its compounds. Dorzolamide may enhance antiepileptic-induced osteomalacia. Use of Dorzolamide with aspirin may result in severe acidosis and increase CNS toxicity. Dorzolamide may affect fluid and electrolyte balance leading to interactions similar to those of the thiazide diuretics. Unlike thiazides, however, Dorzolamide may increase the excretion of lithium. Systemic absorption may occur after topical application of dorzolamide to the eye.,
Ref :-   Book : Martindale    Page : 2002,2007   Edition : 38,


►  Contraindication : Addison’s disease , hepatic impairment, adrenocortical insufficiency, renal impairment, chronic angle-closure glaucoma, Encephalopathy may be precipitated in patients with hepatic dysfunction, patients with a history of sulfonamide hypersensitivity, It should be given with care to patients likely to develop acidosis or with diabetes mellitus; severe metabolic acidosis may occur in the elderly, and in patients with renal impairment, pulmonary obstruction, or emphysema, It may increase the risk of hyperglycaemia in diabetic patients, drowsiness and myopia may affect a patient’s ability to perform skilled tasks including driving,
Ref :-   Book : Martindale    Page : 2002,2006   Edition : 38, Martindale    Page : 2002,2006   Edition : 37,
  ►  Mechanism of Action :   Inhibition of the enzyme prevents dehydration of H2CO3 and hydration of CO2 in the proximal convoluted tubule,
Ref :-   Book : Basic & Clinical pharmacology    Page : 268   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Leaf of Pilocarpus with Another pathway,

  ►  Pathway with its reference as follows :-
  • Pilocarpine and Pilosine produces Anti-Glaucoma effect. --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA