Dosulepin is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 419   Edition : 37      Page :   Edition :   

  ►   Brandname : Prepadine, Prothiaden, Dothapax, Prothiaden M
  ►  Strength : Tablet with .  Capsule with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 419   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 419   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 25 mg t.i.d.

Ref :-  Book : Martindale    Page : 419   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Dry mouth, Urinary retention, Blurred Vision, increase intra-ocular pressure, Seizure, Sedation, Orthostatic hypotension, Sexual disturbance, Hyperthermia, Drowsiness, Insomnia, Headache, Peripheral neuropathy, Tremor, Ataxia, Epileptiform seizures, Tinnitus, Extrapyramidal symptoms, Speech Difficulties, Confusion, Hallucinations, Delirium, Sour taste, Metallic taste, Stomatitis, Gastric irritation, Nausea, Vomiting, Breast enlargement, Galactorrhoea, Increased appetite, Weight gain, Testicular enlargement, Gynaecomastia
Ref :-   Book : Martindale    Page : 406,419   Edition : 37.  

►  Drug Interaction : Drug interaction of Dosulepin is with , , Alcohol, Barbiturates , , Antipsychotic , Calcium Channel Blockers , , , , Monoamine Oxidase Inhibitor,  Rifampicin , Cimetidine , Methylphenidate , Adapalene , Amiodarone , Quinidine , Astemizole, Terfenadine, Pimozide , Sertindole, Thioridazine , Cisapride , Halofantrine, Sotalol
Ref :-   Book : Martindale    Page : 410,419   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce the cytochrome P450 isoenzyme CYP2D6 may affect tricyclic metabolism and produce marked alterations in plasma concentrations. Adverse effects may be enhanced by antimuscarinic drugs or CNS depressants, including alcohol. Barbiturates and other enzyme inducers such as rifampicin and some antiepileptics can increase the metabolism of tricyclic antidepressants and may lower plasma concentrations and reduce antidepressant response. Cimetidine, methylphenidate, antipsychotics, and calciumchannel blockers can reduce the metabolism of the tricyclics, leading to the possibility of increased plasma concentrations and accompanying toxicity. Use of tricyclics with thyroid hormones may precipitate cardiac arrhythmias. The pressor effects of sympathomimetics, especially those of the direct-acting drugs adrenaline and noradrenaline, can be enhanced by tricyclic antidepressants. Drugs that prolong the QT interval, including antiarrhythmics such as amiodarone or quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide, sertindole, and thioridazine), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants. Different antidepressants have been used together under expert supervision in refractory cases of depression, severe adverse reactions including the serotonin syndrome may occur. For this reason an appropriate. Tricyclic antidepressants should not generally be given to patients receiving MAOIs or for at least 2 weeks (3 weeks if starting clomipramine or imipramine) after their withdrawal.
Ref :-   Book : Martindale    Page : 410,419   Edition : 37.  

►  Contraindication : Urinary retention, prostatic hyperplasia, Chronic constipation , Phaeochromocytoma, Epilepsy, cardiovascular disease, Heart block , Hyperthyroidism, Untreated angle-closure glaucoma, Cardiac arrhythmias, Recovery period after myocardial infarction, Hepatic impairment, Severe liver disease, Blood-sugar concentrations may be altered in diabetic patients, Patients should be closely monitored during early antidepressant therapy until significant improvement in depression is observed because suicide is an inherent risk in depressed patients, Regular dental check-ups are recommended for patients on long-term therapy, Drowsiness often occurs, particularly at the start of therapy, and patients, if affected, should not drive or operate machinery, Elderly patients can be particularly sensitive to the adverse effects of tricyclic antidepressants and a reduced dose, especially initially, should be used, Tricyclic antidepressants are not recommended for depression in children
Ref :-   Book : Martindale    Page : 408,419   Edition : 37.  
  ►  Mechanism of Action :   They inhibit the neuronal reuptake of noradrenaline in the CNS; some, in addition, inhibit the reuptake of serotonin (5-HT). Prevention of the reuptake of these monoamine neurotransmitters, which potentiates their action in the brain, appears to be associated with antidepressant activity. Tricyclic antidepressants also possess affinity for muscarinic and histamine H1 receptors to varying degrees.
Ref :-   Book : Martindale    Page : 411,419   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway.  

  ►  Pathway with its reference as follows :-
  • antidepressant effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism), Fecal
    Ref :-   Book : Martindale    Page : 419   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   24 hours.  
    Ref :-   Book : Martindale    Page : 419   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA