Doxapram is a Medicine belongs to CNS Stimulant group whose information about Brand can be referenced from   Book : Martindale    Page : 2355   Edition : 37,

  ►   Brandname : Dopram

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2355   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral,
Reference :-   Book : Martindale    Page : 2355   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute respiratory failure IV infusion 1.5 4 mg/minute Injection
2 Postoperative respiratory depression IV 0.5 1.5 mg/kg Injection Dose: Over a period of at least 30 seconds.

Ref :-  Book : Martindale    Page : 2355   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Neonatal apnoea continuous i.v infusion 2.5 mg/kg Injection
2 Neonatal apnoea Oral 6 mg/kg q.i.d.

Ref :- Book : Martindale    Page : 2355   Edition : 37,
►  Side Effect : dyspnoea, coughing, bronchospasm, laryngospasm, hyperventilation, rebound hypoventilation, Fasciculation, convulsion, headache, Dizziness, hyperactivity, Confusion, sweating, flushing, fever, sensation of warmth, respiratory problems, hiccup, spasticity, ,
Ref :-   Book : Martindale    Page : 2354   Edition : 37,

►  Drug Interaction : Drug interaction of Doxapram is with Halothane , enflurane, Isoflurane ,
Ref :-   Book : Martindale    Page : 2354   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Additive pressor effects may occur when doxapram is used with sympathomimetics or MAOIs. Cardiac arrhythmias may occur when doxapram is given with anaesthetics known to sensitise the myocardium, such as halothane, enflurane, and isoflurane. ,
Ref :-   Book : Martindale    Page : 2355   Edition : 37,


►  Contraindication : Epilepsy, Other convulsive disorders, cerebral oedema, cerebrovascular accident, Head injury, Severe hypotension, Ischaemic heart diseas, hyperthyroidism, phaeochromocytoma, hepatic impairment, renal impairment, acute severe asthma, Physical obstruction of airway,
Ref :-   Book : Martindale    Page : 2354   Edition : 37,
  ►  Mechanism of Action :   Doxapram hydrochloride is a central and respiratory stimulant with a brief duration of action. It acts by stimulation of peripheral chemoreceptors and central respiratory centres; at higher doses, it stimulates other parts of the brain and spinal cord. Doxapram has a pressor action and may also increase catecholamine release,
Ref :-   Book : Martindale    Page : 2355   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Long peper with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antiasthmatic effect --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 2354   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 minute,    Max value :-   2 minutes,
    Ref :-   Book : Martindale    Page : 2355   Edition : 37,