Doxepin is a Medicine belongs to Antidepressant Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 420   Edition : 37,

  ►   Brandname : Prudoxin,Sinequan,Zonalon,Sinepin,Xepin,Deptran,Spectra

  ►  Strength : Capsule with 10  mg, Capsule with 25  mg, Capsule with 50  mg, Capsule with 75  mg, Capsule with 100  mg, Capsule with 150  mg, Solution with 10  mg/ml, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12, Martindale    Page : 420   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV,
Reference :-   Book : Martindale    Page : 420   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Insomnia Oral 6 mg o.d. The dose should be taken with in 30 minutes of bedtime
2 Depression Oral 75 mg Capsule Dose: Given daily

Ref :-  Book : Martindale    Page : 420   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : drowsiness, burning , stinging, dry mouth, urinary retention, Blurred Vision, increase intra-ocular pressure, seizure, Sedation, Orthostatic hypotension, sexual disturbance, hyperthermia, insomnia, headache, peripheral neuropathy, tremor, ataxia, epileptiform seizures, tinnitus, extrapyramidal symptoms, speech difficulties (dysarthria), Confusion, hallucinations, delirium, sour taste, metallic taste, stomatitis, gastric irritation, nausea, vomiting, breast engorgement, galactorrhoea, Increased appetite, weight gain, testicular enlargement, Gynaecomastia,
Ref :-   Book : Martindale    Page : 406,419   Edition : 37,

►  Drug Interaction : Drug interaction of Doxepin is with , , Alcohol, Barbiturates , , Antipsychotic , Calcium Channel Blockers , , , , Monoamine Oxidase Inhibitors,  Rifampicin , Cimetidine , Methylphenidate , Adapalene , Amiodarone , Quinidine , Astemizole, Terfenadine, Pimozide , Sertindole, Thioridazine , Cisapride , Halofantrine, Sotalol ,
Ref :-   Book : Martindale    Page : 410,419   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce the cytochrome P450 isoenzyme CYP2D6 may affect tricyclic metabolism and produce marked alterations in plasma concentrations. Adverse effects may be enhanced by antimuscarinic drugs or CNS depressants, including alcohol. Barbiturates and other enzyme inducers such as rifampicin and some antiepileptics can increase the metabolism of tricyclic antidepressants and may lower plasma concentrations and reduce antidepressant response. Cimetidine, methylphenidate, antipsychotics, and calciumchannel blockers can reduce the metabolism of the tricyclics, leading to the possibility of increased plasma concentrations and accompanying toxicity. Use of tricyclics with thyroid hormones may precipitate cardiac arrhythmias. The pressor effects of sympathomimetics, especially those of the direct-acting drugs adrenaline and noradrenaline, can be enhanced by tricyclic antidepressants. Drugs that prolong the QT interval, including antiarrhythmics such as amiodarone or quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide, sertindole, and thioridazine), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants. Different antidepressants have been used together under expert supervision in refractory cases of depression, severe adverse reactions including the serotonin syndrome may occur. For this reason an appropriate. Tricyclic antidepressants should not generally be given to patients receiving MAOIs or for at least 2 weeks (3 weeks if starting clomipramine or imipramine) after their withdrawal,
Ref :-   Book : Martindale    Page : 410,419   Edition : 37,


►  Contraindication : urinary retention, prostatic hyperplasia, chronic constipation , phaeochromocytoma, Epilepsy, cardiovascular disease, heart block , hyperthyroidism, Untreated angle-closure glaucoma, Cardiac arrhythmias, Recovery period after myocardial infarction, hepatic impairment, severe liver disease, Blood-sugar concentrations may be altered in diabetic patients, Patients should be closely monitored during early antidepressant therapy until significant improvement in depression is observed because suicide is an inherent risk in depressed patients, regular dental check-ups are recommended for patients on long-term therapy, Drowsiness often occurs, particularly at the start of therapy, and patients, if affected, should not drive or operate machinery, Elderly patients can be particularly sensitive to the adverse effects of tricyclic antidepressants and a reduced dose, especially initially, should be used, Tricyclic antidepressants are not recommended for depression in children,
Ref :-   Book : Martindale    Page : 408,419   Edition : 37,
  ►  Mechanism of Action :   It causes mixed and variable blockade of norepinephrine transporter and serotonin transporter,
Ref :-   Book : Basic & Clinical pharmacology    Page : 538   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • antidepressant effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 420   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   8 hours,    Max value :-   24 hours,
    Ref :-   Book : Martindale    Page : 419   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA