Doxofylline is a Medicine belongs to bronchodilator group whose information about Brand can be referenced from   Book : Martindale    Page : 1234   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Ansimar,Axofin,Puroxan,Doxobid,Doxomax XP

  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, slow i.v,
Reference :-   Book : Martindale    Page : 1233   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Reversible airways obstruction Oral 1.2 gm Dose; Given daily

Ref :-  Book : Martindale    Page : 1233   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, abdominal pain, diarrhea, gastrointestinal disturbance, insomnia, headache, anxiety, irritability, Restlessness, tremor, palpitations, convulsion, Cardiac arrhythmias, Severe hypotension, cardiac arrest, fatalities,
Ref :-   Book : Martindale    Page : 1233,1255   Edition : 37,

►  Drug Interaction : Drug interaction of Doxofylline is with , , , Macrolide, Quinolones, Oral Contraceptive, Beta 2 Agonist, Diuretic Agents , Competitive neuromuscular blockers,  Allopurinol , Cimetidine , Disulfiram, Fluvoxamine, Tiabendazole, Viloxazine, Phenytoin , Ritonavir, Rifampicin , Sulfinpyrazone, Corticosteroids, Halothane , Ketamine ,
Ref :-   Book : Martindale    Page : 1233,1257   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Doxofylline clearance may be reduced by interaction with other drugs including allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon alfa, macrolide antibacterials and quinolones, oral contraceptives, tiabendazole, and viloxazine, and the dose of doxofylline may need to be reduced. Phenytoin and some other antiepileptics, ritonavir, rifampicin, and sulfinpyrazone may increase doxofylline clearance, and require an increase in dose or dosing frequency of doxofylline. Xanthines can potentiate hypokalaemia caused by hypoxia or associated with the use of beta2-adrenoceptor stimulants (beta2 agonists), corticosteroids, and diuretics. There is a risk of synergistic toxicity doxofylline if is given with halothane or ketamine, and it may antagonise the effects of adenosine and of competitive neuromuscular blockers; lithium elimination may be enhanced with a consequent loss of effect. ,
Ref :-   Book : Martindale    Page : 1233,1257   Edition : 37,


►  Contraindication : Peptic ulceration, Porphyria, hyperthyroidism, Epilepsy, heart failure, Other cardiovascular disease, hepatic dysfunction, acute febrile illness,
Ref :-   Book : Martindale    Page : 1233,1257   Edition : 37,
  ►  Mechanism of Action :   It is a xanthine and relaxes bronchial smooth muscle, relieves bronchospasm, and has a stimulant effect on respiration. It stimulates the myocardium and CNS, decreases peripheral resistance and venous pressure, and causes diuresis. It is still not clear how theophylline exerts these effects. Inhibition of phosphodiesterase with a resulting increase in intracellular cyclic adenosine monophosphate (cyclic AMP) occurs, and may play a role. Other proposed mechanisms of action include adenosine receptor antagonism, prostaglandin antagonism, and effects on intracellular calcium. In addition, theophylline may also have an anti-inflammatory effect. ,
Ref :-   Book : Martindale    Page : 1233,1261-1262   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • antitussive effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA