Doxorubicin is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 783   Edition : 37,

  ►   Brandname : Adrim,Cadria,Duxocin,Oncodox,Caelyx,Myocet,Doxil,Rubex

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 783   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, intra-arterial injection,
Reference :-   Book : Martindale    Page : 782   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 IV 1.2 2.4 mg/kg Injection Dose: Given once every 3 weeks, Doxorubicin hydrochloride is given by intravenous injection into a fast-running infusion of sodium chloride 0.9% or glucose 5% over 3 minutes or more.
2 IV 60 75 mg/m2 Injection Dose; Given once every 3 or 4 weeks, Doxorubicin hydrochloride is given by intravenous injection into a fast-running infusion of sodium chloride 0.9% or glucose 5% over 3 minutes or more.
3 Malignant neoplasm of bladder 1 mg/ml Injection 50 mL of a 1 mg/mL solution may be instilled into the bladder for about one hour.
4 AIDS-related kaposi's sarcoma IV infusion 20 mg/m2 Injection Dose: Given over 30 minutes once every 2 to 3 weeks.

Ref :-  Book : Martindale    Page : 782   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : mucositis, alopecia, gastrointestinal disturbance, bone marrow depression, ECG abnormalities, vomiting, stomatitis, oesophagitis, haemorrhagic cystitis, facial flushing, conjunctivitis, transient disturbance of cardiac function, Severe cardiotoxicity, Occasional hypersensitivity, Lacrimation, Local necrosis, urethral irritation, haematuria, nausea, hyperuricaemia, Hyperpigmentation of the oral mucosa and/ or nails, Onycholysis, drowsiness, renal damage, Hepatic damage, Transient increases in liver enzymes, thrombophlebitis, ,
Ref :-   Book : Martindale    Page : 780   Edition : 37,

►  Drug Interaction : Drug interaction of Doxorubicin is with Live Vaccines, ,  Daunorubicin (Daunomycin), Cyclopentolate , Cyclophosphamide , Stavudine, Lincomycin,
Ref :-   Book : Martindale    Page : 698, 781   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The cumulative dose of doxorubicin should be reduced in patients who have received other cardiotoxic drugs such as daunorubicin or cyclophosphamide. Doxorubicin is reported to inhibit the intracellular activation of stavudine and hence its antiviral effect. antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines possibility of generalized infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted.,
Ref :-   Book : Martindale    Page : 698,781   Edition : 37,


►  Contraindication : Cardiac disease, hepatic impairment, Pregnancy, Breast feeding, Great caution is needed when the marrow is already depressed from radiotherapy or therapy with other antineoplastics, and modification of dosage regimens may be required,
Ref :-   Book : Martindale    Page : 697,781   Edition : 37,
  ►  Mechanism of Action :   Doxorubicin is an anthracycline antineoplastic antibiotic. It is thought to have multiple modes of action including intercalation of DNA leading to an inhibition of DNA and RNA synthesis, inhibition of topoisomerase II, free radical formation, and alterations in cell membranes. Doxorubicin is a cell-cycle non-specific agent.,
Ref :-   Book : Martindale    Page : 782   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway, Asparagus with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vincristine arrests multiplication of cancerous cells by breaking down the microtubules into smaller subunits, thus inhibiting the cell division. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Anticancer effect --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B2 with Decrease in Nutrient Level, VITAMIN E with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- L-CARNITINE with It may prevant drug toxicity , CO Q10 with Coenzyme Q10 before administration of doxorubicin has reduced cardiac toxicity ., MELATONIN with It decreassssed toxicity and improved effectiveness of chemotherapy with doxorubicin ., VITAMIN E with Increase vitamin E oxidation .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 780   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA