Doxycycline is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 291,292   Edition : 37,

  ►   Brandname : Biodoxi,Doxicip,Alodox,Atridox,Doryx,Doxsig,Doxy,Doxyhexal,Doxylin,Aknefug Doxy,Antodox,Atridox

  ►  Strength : Capsule with 20  mg, Capsule with 50  mg, Capsule with 100  mg, Tablet with 50  mg, Tablet with 100  mg, Suspension with 25/5  mg/ml, Syrup with 50/5  mg/ml, Injection with 100  mg, Injection with 200  mg, Delayed- release tablets with   , Delayed-release capules with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12, Martindale    Page : 291   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 291   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated gonococcal infections Oral 100 mg b.d. Dose: Given for 7 days, although it has occasionally been given in a single dose of 300 mg followed by a second similar dose 1 hour later
2 Syphilis Oral 100 200 mg b.d. Dose: In penicillin-allergic patients: Given for at least 14 days
3 Relapsing fever Oral 100 200 mg Dose: Given as a single oral dose
4 Louse-borne typhus Oral 100 200 mg Dose: Given as a single oral dose
5 Prophylaxis of scrub typhus Oral 200 mg Dose: Given as a single oral dose
6 Prophylaxis of leptospirosis Oral 200 mg QWK Dose: Given throughout exposure for up to 21 days and 200 mg is also given when leaving the area of infection risk
7 Chloroquine-resistant falciparum malaria Oral 200 mg Dose: Given daily for 7 days after treatment with quinine
8 Treatment of inhalation anthrax Oral 100 mg b.d. Dose: Given as a 60-day course; one or two other antibacterials should also be given.
9 Cutaneous anthrax Oral 100 mg b.d. Dose: Given as a 7- to 10-day course; treatment may need to be extended to 60 days if infection is due to aerosol exposure
10 Acne vulgaris Oral 50 mg Dose: Given daily for 6 to 12 weeks
11 Chronic periodontitis Oral 10 % Gel Dose: (released over 7 days) inserted into the periodontal pocket
12 Postexposure prophylaxis of inhalation anthrax Oral 100 mg Dose: Given as a 60-day course; one or two other antibacterials should also be given
13 Periodontitis Oral 20 mg b.d. Dose: Given for 3 months as an adjunct to supragingival and subgingival scaling and root planing to adults with periodontitis
14 Susceptible bacterial infections Oral 200 mg Dose: Given on the first day (as a single dose or in divided doses), followed by
15 Susceptible bacterial infections IV 200 mg Injection Dose: Given on the first day (as a single dose or in divided doses), followed by

Ref :-  Book : Martindale    Page : 291   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antibacterials 12 years and over Oral 200 mg
2 Antibacterials 12 years and over IV 200 mg Injection
3 Rocky Mountain spotted fever Less than 45 kg Oral 2.2 mg/kg b.d.
4 Prophylaxis of chloroquine-resistant falciparum malaria Over 8 year old Oral 2 mg/kg o.d.
5 Rocky Mountain spotted fever Less than 45 kg IV 2.2 mg/kg Injection b.d.
6 Treatment and postexposure prophylaxis of inhalation anthrax Oral 2.2 mg/kg b.d.
7 Treatment and postexposure prophylaxis of inhalation anthrax IV 2.2 mg/kg Injection b.d.

Ref :- Book : Martindale    Page : 291   Edition : 37,
Precaution :- If a Patient is using 'Doxycycline' drug in  Urinary Tract Infection  disease, then Please contraindicated in lactation .

Precaution :- If a Patient is using 'Doxycycline' drug in  PID  disease, then Please Contraindication: pregnancy, lactation .

Precaution :- If a Patient is using 'Doxycycline' drug in  thallasemia  disease, then Please Avoid .

►  Side Effect : nausea, vomiting, diarrhoea, oesophageal ulceration, glossitis, stomatitis, dysphagia, oral candidiasis, vulvovaginitis, Pruritus ani, Renal dysfunction, hepatotoxicity, permanent discoloration of teeth, enamel hypoplasia, nail discoloration, Onycholysis, intracranial hypertension, headache, Dizziness, tinnitus, visual disturbances, papilloedema, muscle weakness, hypersensitivity reactions, Rashes, fixed drug eruptions, exfoliative dermatitis, toxic epidermal necrolysis, drug fever, pericarditis, angioedema, Urticaria, asthma, photosensitivity, local pain, Irritation, thrombophlebitis, Jarisch- Herxheimer reaction, hypoprothrombinaemia, ,
Ref :-   Book : Martindale    Page : 290,377   Edition : 37,

►  Drug Interaction : Drug interaction of Doxycycline is with Antacid , , Diuretic Agents , Nephrotoxic drugs, , Alcohol, Antiepileptics , ,  Iron , Methoxyflurane, Rifampicin , Carbamazapine , Phenobarbital , Phenytoin , Primidone , Cidofovir ,
Ref :-   Book : Martindale    Page : 290,378   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Use of Doxycycline with antacids, iron preparations, some foods such as milk and dairy products, may result in subtherapeutic serum concentrations. The nephrotoxic effects may be exacerbated by diuretics, methoxyflurane, or other potentially nephrotoxic drugs, Doxycycline has a lower affinity for binding with calcium than many tetracyclines. Consequently its absorption is less likely to be affected by milk or food, although it is still affected by calcium-containing antacids and other divalent and trivalent cations such as aluminium, bismuth, iron, magnesium, and zinc; even intravenous doxycycline may be affected, although less so than when given orally. The metabolism of doxycycline may be accelerated by drugs that induce hepatic enzymes such as alcohol (chronic use), rifampicin, and antiepileptics including carbamazepine, phenobarbital, phenytoin, and primidone. It has been suggested that doxycycline could increase ciclosporin concentrations, but evidence for this seems to be scant.,
Ref :-   Book : Martindale    Page : 290,378   Edition : 37,


►  Contraindication : Hypersensitive to any of this group of antibacterials, since cross-sensitivity may occur, Pregnancy, hepatic impairment, Renal artery stenosis, Systemic Lupus Erythematosus (SLE),
Ref :-   Book : Martindale    Page : 290,378   Edition : 37,
  ►  Mechanism of Action :   Doxycycline is broad-spectrum bacteriostatic antibiotics that inhibit protein synthesis. Doxycycline enter microorganisms in part by passive diffusion and in part by an energy-dependent process of active transport. Susceptible organisms concentrate the drug intracellularly. Once inside the cell, Doxycycline bind reversibly to the 30S subunit of the bacterial ribosome , blocking the binding of aminoacyl-tRNA to the acceptor site on the mRNA ribosome complex. This prevents addition of amino acids to the growing peptide.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 810   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway, Neem oil with Another pathwayAnother pathway, Neem oil with Another pathwayAnother pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotics property --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Nimbidin have Antibiotic and Anti-bacterial effect. --- (Gupta, D. (2016). Antibacterial effect of Neem oil on Methicillin resistant Staphylococcus aureus. Journal Of Medicinal Plants Studie, 4(1). )
  • Nimbidin have Antibiotic and Anti-bacterial effect. --- (Gupta, D. (2016). Antibacterial effect of Neem oil on Methicillin resistant Staphylococcus aureus. Journal Of Medicinal Plants Studie, 4(1). )
  • Nimbidin have Antibiotic and Anti-bacterial effect. --- (Gupta, D. (2016). Antibacterial effect of Neem oil on Methicillin resistant Staphylococcus aureus. Journal Of Medicinal Plants Studie, 4(1). )
  • Nimbidin have Antibiotic and Anti-bacterial effect. --- (Gupta, D. (2016). Antibacterial effect of Neem oil on Methicillin resistant Staphylococcus aureus. Journal Of Medicinal Plants Studie, 4(1). )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, http://www.plantsjournal.com/archives/2016/vol4issue1/PartA/3-6-33.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Dietary Substance is Drug Inhibitor, MAGNESIUM with Dietary Substance is Drug Inhibitor, ZINC with Dietary Substance is Drug Inhibitor, BERBERIS HETEROPODA with Dietary Substance is Drug Inhibitor, IRON with Decrease in Nutrient Level,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 291   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   12 hours,    Max value :-   24 hours,
    Ref :-   Book : Martindale    Page : 291   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Goodman    Page : 1924   Edition : 12,