Doxylamine Succinate is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 629   Edition : 37,

  ►   Brandname : Dozile,Restavit,Gittalun,Hoggar Night,Aldex AN,Unisom SleepTabs

  ►  Strength : Syrup with   , Tablet with   , Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 629   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 629   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypnotic Oral 25 mg Dose: usual hypnotic dose, given up to half an hour before bedtime

Ref :-  Book : Martindale    Page : 629   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : CNS depression, slight drowsiness to deep sleep, lassitude, Dizziness, incoordination, headache, psychomotor impairment, dry mouth, thickened respiratory-tract secretions, Blurred Vision, urinary difficulty, urinary retention, constipation, increased gastric reflux, convulsion, sweating, myalgia, paraesthesia, extrapyramidal effects, tremor, Sleep disturbances, Confusion, tinnitus, hypotension, hair loss, nausea, vomiting, diarrhea, epigastric pain, hypersensitivity reactions, bronchospasm, angioedema, anaphylaxis, Rashes, Depression, ,
Ref :-   Book : Martindale    Page : 611,629   Edition : 37,

►  Drug Interaction : Drug interaction of Doxylamine Succinate is with Alcohol, Barbiturates , Hypnotic , Opoid analgesic , Anxiolytic sedatives, Antipsychotic , Antimuscarinic, ,  Atropine ,
Ref :-   Book : Martindale    Page : 613,629   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs) ,
Ref :-   Book : Martindale    Page : 613,629   Edition : 37,


►  Contraindication : urinary retention, Drowsiness is a major problem with the sedating antihistamines and those affected should not drive or operate machinery; alcohol should be avoided, angle-closure glaucoma, prostatic hyperplasia, pyloroduodenal obstruction, renal impairment,
Ref :-   Book : Martindale    Page : 612,629   Edition : 37,
  ►  Mechanism of Action :   Doxylamine succinate, a monoethanolamine derivative, is a sedating antihistamine with antimuscarinic and pronounced sedative effects.,
Ref :-   Book : Martindale    Page : 629   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Lemon with Another pathway, Onion with Another pathwaysame pathway, Onion with Another pathwaysame pathway,

  ►  Pathway with its reference as follows :-
  • Antihistaminic effect. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Antihistaminic effect. --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Antihistaminic effect. --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Antihistaminic effect. --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Antihistaminic effect. --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   10 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 629   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 629   Edition : 37,