Duloxetine is a Medicine belongs to Antidepressant Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 421   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Delok,Cymbalta,Yentreve,duloren,Dxt,Duloxee

  ►  Strength : Capsule with 20  mg, Capsule with 30  mg, Capsule with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 421   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 20 30 mg Capsule b.d.
2 Generalised anxiety disorder Oral 30 60 mg Capsule o.d.
3 Fibromyalgia Oral 30 mg Capsule Dose given daily for the first week to allow patients to adjust the effects of duloxetine, then increased to 60 mg once daily if necessary
4 Peripheral neuropathic pain Oral 60 mg Capsule o.d.
5 Severe stress urinary incontinence Oral 40 mg Capsule b.d.
6 Depression Oral 60 mg Capsule o.d.

Ref :-  Book : Martindale    Page : 421   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, headache, insomnia, fatigue, Somnolence, dry mouth, Dizziness, constipation, anorexia, diarrhea, dyspepsia, vomiting, anxiety, visual disturbances, tremor, weight gain, weight loss, sexual dysfunction, Nervousness, lethargy, hot flushes, increased sweating, pruritus, Orthostatic hypotension, syncope, serotonin syndrome, akathisia, increase in liver enzymes, tachycardia, ecchymoses, Skin rashes, photosensitivity reactions, hepatitis, cholestatic jaundice, suicidal ideation, yawning, increases in blood pressure , ,
Ref :-   Book : Martindale    Page : 420   Edition : 37,

►  Drug Interaction : Drug interaction of Duloxetine is with , , , , Monoamine Oxidase Inhibitor, , selective serotonin reuptake inhibitors, Noradrenaline Reuptake Inhibitor, Reversible Inhibitors Of Monoamine Oxidase,  Fluvoxamine, Ciprofloxacin , Enoxacin, paroxetine,
Ref :-   Book : Martindale    Page : 420   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Duloxetine is metabolised by the cytochrome P450 isoenzymes CYP1A2 and CYP2D6. It should not be given with potent inhibitors of CYP1A2 such as fluvoxamine, ciprofloxacin, and enoxacin as such combinations are likely to result in increased duloxetine concentrations. Similarly, caution is recommended when duloxetine is given with potent CYP2D6 inhibitors such as paroxetine. Duloxetine itself is also a moderate inhibitor of CYP2D6. Duloxetine should not be used with MAOIs and at least 14 days should elapse between stopping an MAOI and starting treatment with duloxetine. The use of duloxetine with other antidepressants including the SSRIs, other serotonin and noradrenaline reuptake inhibitors, and the reversible inhibitors of monoamine oxidase is not recommended.,
Ref :-   Book : Martindale    Page : 420   Edition : 37,


►  Contraindication : hepatic impairment, severe renal impairment, hypertension, Uncontrolled narrow-angle glaucoma, It should be used with caution in patients with a history of seizures, of bleeding disorders, or of hypomania or mania, It may impair performance of skilled tasks and, if affected, patients should not drive or operate machinery,
Ref :-   Book : Martindale    Page : 420   Edition : 37,
  ►  Mechanism of Action :   Block 5-HT reuptake transporter and NE reuptake transporter in a concentration- dependent manner,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 222   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fish with Another pathway, Pineapple with Another pathway, Soy Protein with Another pathway, Milk with Another pathway,

  ►  Pathway with its reference as follows :-
  • Rich in tryptophan & raised serotonin level . --- ( m, Ahmad. "Preparation And Evaluation Of A Novel Therapeutic Dairy-Based Drink For Phenylketonuria". North Americal Journal Of Medical Sciences 2.2 (2010): 66–70. Web. 27 Sept. 2016. )
  • Rich in tryptophan & raised serotonin level . --- (m, Ahmad. "Preparation And Evaluation Of A Novel Therapeutic Dairy-Based Drink For Phenylketonuria". North Americal Journal Of Medical Sciences 2.2 (2010): 66–70. Web. 27 Sept. 2016. )
  • Rich in tyrosine & convert into L-dopa which is precursor of epinephrine. --- (m, Ahmad. "Preparation And Evaluation Of A Novel Therapeutic Dairy-Based Drink For Phenylketonuria". North Americal Journal Of Medical Sciences 2.2 (2010): 66–70. Web. 27 Sept. 2016. )
  • Rich in phenylalanine & converted into L -dopa which is precersor of epinephrinre. --- ( m, Ahmad. "Preparation And Evaluation Of A Novel Therapeutic Dairy-Based Drink For Phenylketonuria". North Americal Journal Of Medical Sciences 2.2 (2010): 66–70. Web. 27 Sept. 2016. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242935/, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354437/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 421   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   8 hours,    Max value :-   17 hours,
    Ref :-   Book : Martindale    Page : 421   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   6 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 421   Edition : 37,