Dydrogesterone is a Medicine belongs to Sex hormones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2302   Edition : 37  

  ►   Brandname : Duphaston
  ►  Strength : Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2302   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2302   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menorrhagia Oral 10 mg Tablet b.d. Dose: Given in a cyclical regimen
2 Endometriosis Oral 10 mg Tablet b.d/t.i.d Dose given cyclically or continuously
3 Threatened miscarriage Oral 40 mg Tablet Dose: followed by 10 mg or more every 8 hours, continued for a week after symptoms cease then gradually reduced unless symptoms return.
4 Recurrent miscarriage Oral 10 mg Tablet b.d. Dose: Given cyclically until conception then continuously until week 20 of pregnancy, the dose may then be gradually reduced
5 Infertility Oral 10 mg Tablet b.d.
6 Endometrial protection during menopausal HRT Oral 10 mg Tablet o.d/b.d Dose: given cyclically, or continuously in doses of 5 mg daily.

Ref :-  Book : Martindale    Page : 2302   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Gastrointestinal disturbance, Changes in appetite, Fluid retention, Oedema, Allergic skin rashes, Urticaria, Mental depression, Gynaecomastia, Changes in libido, Hair loss, Hirsutism, Fatigue, Drowsiness, Insomnia, Fever, Headache, Premenstrual syndrome-like symptoms, Altered menstrual cycles, Anaphylactoid reactions, Irregular menstrual bleeding, Breast changes, Chloasma (melasma), Changes in weight, Alterations in serum lipid profile
Ref :-   Book : Martindale    Page : 2302,2333   Edition : 37.  

►  Drug Interaction : Drug interaction of Dydrogesterone is with ,  Carbamazapine , Griseofulvin , Phenobarbital , Phenytoin , Rifampicin , Aminoglutethimide
Ref :-   Book : Martindale    Page : 2302,2333   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs such as carbamazepine, griseofulvin, phenobarbital, phenytoin, and rifampicin may enhance the clearance of dydrogesterone. These interactions are likely to reduce the efficacy of dydrogesterone-only contraceptives, and additional or alternative contraceptive measures are recommended. Aminoglutethimide markedly reduces the plasma concentrations of dydrogesterone possibly through a hepatic enzyme-inducing effect; an increase in dydrogesterone dose is likely to be required. Since dydrogesterone can influence diabetic control an adjustment in antidiabetic dosage could be required. Dydrogesterone may inhibit ciclosporin metabolism leading to increased plasma ciclosporin concentrations and a risk of toxicity.
Ref :-   Book : Martindale    Page : 2302,2333   Edition : 37.  

►  Contraindication : Hypertension, Renal impairment, Asthma, Epilepsy, Migraine, Cardiac impairment, Other conditions which may be aggravated by fluid retention, Undiagnosed vaginal bleeding, History or current high risk of arterial disease, Hepatic impairment, Breast or genital- tract carcinoma
Ref :-   Book : Martindale    Page : 2302,2333   Edition : 37.  
  ►  Mechanism of Action :   The progesterone-receptor complex forms adimer before binding to DNA. Like the estrogen receptor, it can form heterodimers as well as homodimers between to isomers, A and B. These isoforms are produced by alternative splicing of the same gene.
Ref :-   Book : Basic & Clinical pharmacology    Page : 723   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA