Echothiophate Iodide is a Medicine belongs to Anticholinesterase group whose information about Brand can be referenced from   Book : Martindale    Page : 2007   Edition : 38,

  ►   Brandname :
Phospholine iodide


  ►  Strength :
Ophthalmic Solution with 0.03  %, Ophthalmic Solution with 0.06  %, Ophthalmic Solution with 0.125  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration :
ophthalmic,
Reference :-   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Open-angle glaucoma ophthalmic 0.125 % Eye Drop

Ref :-  Book : Martindale    Page : 2007   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect :
Acute iritis, retinal detachment, precipitation of acute glaucoma, iris cysts, Miosis,
Ref :-   Book : Martindale    Page : 2007   Edition : 38,
►  Drug Interaction : Drug interaction of Echothiophate Iodide is with
Aminoglycoside antibiotic , Cyclophosphamide, , Halogenated inhalational anaesthetics,  Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Felbamate, Suxamethonium chloride, Neostigmine , Clindamycin , Colistin, Cyclopentolate , Atropine ,
Ref :-   Book : Martindale    Page : 687,2043   Edition : 37,

  ►    Mechanism of Drug Drug Interaction : 
Drugs with neuromuscular blocking activity, such as the aminoglycosides, clindamycin, colistin, cyclopropane, and the halogenated inhalational anaesthetics, may antagonise the effects of echothiophate. Those such as quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, and the beta blockers, that have the potential to aggravate myasthenia gravis, can reduce the effectiveness of treatment with parasympathomimetics. Prolonged bradycardia has also occurred in patients receiving beta blockers when given neostigmine. Anticholinesterases, such as echothiophate, can inhibit the metabolism of suxamethonium and enhance and prolong its action; combined use is not recommended. Ophthalmic use of anticholinesterases, such as ecothiopate, should be undertaken with care in patients receiving neostigmine systemically for myastheniab gravis, because of possible additive toxicity. Antimuscarinics such as atropine antagonise the muscarinic effects of echothiophate.,
Ref :-   Book : Martindale    Page : 687,2043   Edition : 37,

►  Contraindication :
hypersensitive to iodine,
Ref :-   Book : Martindale    Page : 2043   Edition : 37,
  ►  Mechanism of Action :  
Acetylcholinesterase is the primary target of these drugs, but butyrylcholinesterase is also inhibited. All the cholinesterase inhibitors increase the concentration of endogenous acetylcholine at cholinoceptors by inhibiting acetylcholinesterase,
Ref :-   Book : Basic & Clinical pharmacology    Page : 106   Edition : 12,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Black current with same pathway,

  ►  Pathway with its reference as follows :-
  • Black current having active constituent kaempferol which act as acetylcholinesterase inhibitor . --- (Murray, A., Faraoni, M., Castro, M., Alza, N., & Cavallaro, V. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Current Neuropharmacology, 11(4), 388-413. http://dx.doi.org/10.2174/1570159x11311040004 )

    •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/,


    Dietry Substance Interactions

    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :  
    Renal,
    Ref :-   Book : Goodman    Page : 247   Edition : 12,

    ►    Plasma Half-life :      
    Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :  
    Min value :-   NA    Max value :-   NA