Echothiophate Iodide is a Medicine belongs to
Anticholinesterase
group whose information about Brand can be referenced from
Book :
Martindale Page : 2007 Edition : 38
► Brandname :
Phospholine iodide
Brand :
Phospholine iodide
Book : Martindale Page : 2007 Edition : 38
► Strength :
Ophthalmic Solution
with 0.03
%. Ophthalmic Solution
with 0.06
%. Ophthalmic Solution
with 0.125
%.
Reference of this Medicine for its Strength can be taken from Book : Basic & Clinical pharmacology Page : 112 Edition : 12
Strength :
Ophthalmic Solution
with 0.03
%. Ophthalmic Solution
with 0.06
%. Ophthalmic Solution
with 0.125
%.
Book : Basic & Clinical pharmacology Page : 112 Edition : 12
► Brandname :
Phospholine iodide
Brandname
Brand :
Phospholine iodide Book : Martindale Page : 2007 Edition : 38
► Strength :
Ophthalmic Solution
with 0.03
%. Ophthalmic Solution
with 0.06
%. Ophthalmic Solution
with 0.125
%. Reference of this Medicine for its Strength can be taken from Book : Basic & Clinical pharmacology Page : 112 Edition : 12
Strength
Strength :
Ophthalmic Solution
with 0.03
%. Ophthalmic Solution
with 0.06
%. Ophthalmic Solution
with 0.125
%. Book : Basic & Clinical pharmacology Page : 112 Edition : 12
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.
► Route of administration :
ophthalmic
Reference :- Book : Basic & Clinical pharmacology Page : 112 Edition : 12
Route of administration :
ophthalmic
Book : Basic & Clinical pharmacology Page : 112 Edition : 12
► Route of administration :
ophthalmic
Reference :- Book : Basic & Clinical pharmacology Page : 112 Edition : 12
Route of administration
Route of administration :
ophthalmic
Book : Basic & Clinical pharmacology Page : 112 Edition : 12
Dosing of Medicine differ in Adult & Pediatrics ↓
Ref :- Book : Martindale Page : 2007 Edition : 38
Ref :- Book : Page : Edition :
Adult Dose
| S.No | Ailment | Route | Dose Min | Dose Max | Unit | Dosage Form | Frequency | Additional Info |
|---|---|---|---|---|---|---|---|---|
| 1 | Open-angle glaucoma | ophthalmic | 0.125 | % | Eye Drop |
Adult Dose
| S.No | Ailment | Route | Dose Min | Dose Max | Unit | Dosage Form | Frequency | Additional Info |
|---|---|---|---|---|---|---|---|---|
| 1 | Open-angle glaucoma | ophthalmic | 0.125 | % | Eye Drop |
Ref :- Book : Martindale Page : 2007 Edition : 38
Pediatric Dose
| S.No | Ailment | Age Min | Age Max | Weight ( Kg ) | Route | Dose Min | Dose Max | Unit | Dosage Form | Additional Info |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
Pediatric Dose
| S.No | Ailment | Age Min | Age Max | Weight ( Kg ) | Route | Dose Min | Dose Max | Unit | Dosage Form | Frequency | Additional Info |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
Ref :- Book : Page : Edition :
► Side Effect :
Acute iritis, Retinal detachment, Precipitation of acute glaucoma, Iris cysts, Miosis
Ref :- Book : Martindale Page : 2007 Edition : 38.
Side Effect
Side Effect :
Acute iritis, Retinal detachment, Precipitation of acute glaucoma, Iris cysts, Miosis
Book : Martindale Page : 2007 Edition : 38.
► Drug Interaction : Drug interaction of Echothiophate Iodide is with
Aminoglycoside antibiotic , Cyclophosphamide, , Halogenated inhalational anaesthetics,
Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Felbamate, Suxamethonium chloride, Neostigmine , Clindamycin , Colistin, Cyclopentolate , Atropine Ref :- Book : Martindale Page : 687,2043 Edition : 37.
Drug interaction
Drug Interaction : Drug interaction of Echothiophate Iodide is with
Aminoglycoside antibiotic , Cyclophosphamide, , Halogenated inhalational anaesthetics,
Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Felbamate, Suxamethonium chloride, Neostigmine , Clindamycin , Colistin, Cyclopentolate , Atropine
Book : Martindale Page : 687,2043 Edition : 37.
► Mechanism of Drug Drug Interaction :
Drugs with neuromuscular blocking activity, such as the aminoglycosides, clindamycin, colistin, cyclopropane, and the halogenated inhalational anaesthetics, may antagonise the effects of echothiophate. Those such as quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, and the beta blockers, that have the potential to aggravate myasthenia gravis, can reduce the effectiveness of treatment with parasympathomimetics. Prolonged bradycardia has also occurred in patients receiving beta blockers when given neostigmine. Anticholinesterases, such as echothiophate, can inhibit the metabolism of suxamethonium and enhance and prolong its action; combined use is not recommended. Ophthalmic use of anticholinesterases, such as ecothiopate, should be undertaken with care in patients receiving neostigmine systemically for myastheniab gravis, because of possible additive toxicity. Antimuscarinics such as atropine antagonise the muscarinic effects of echothiophate.
Ref :- Book : Martindale Page : 687,2043 Edition : 37.
Mechanism of Drug
Mechanism of Drug Drug Interaction :
Drugs with neuromuscular blocking activity, such as the aminoglycosides, clindamycin, colistin, cyclopropane, and the halogenated inhalational anaesthetics, may antagonise the effects of echothiophate. Those such as quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, and the beta blockers, that have the potential to aggravate myasthenia gravis, can reduce the effectiveness of treatment with parasympathomimetics. Prolonged bradycardia has also occurred in patients receiving beta blockers when given neostigmine. Anticholinesterases, such as echothiophate, can inhibit the metabolism of suxamethonium and enhance and prolong its action; combined use is not recommended. Ophthalmic use of anticholinesterases, such as ecothiopate, should be undertaken with care in patients receiving neostigmine systemically for myastheniab gravis, because of possible additive toxicity. Antimuscarinics such as atropine antagonise the muscarinic effects of echothiophate.
Book : Martindale Page : 687,2043 Edition : 37.
► Contraindication :
Hypersensitive to iodine
Ref :- Book : Martindale Page : 2043 Edition : 37.
Contraindication
Contraindication :
Hypersensitive to iodine
Book : Martindale Page : 2043 Edition : 37.
► Mechanism of Action :
Acetylcholinesterase is the primary target of these drugs, but butyrylcholinesterase is also inhibited. All the cholinesterase inhibitors increase the concentration of endogenous acetylcholine at cholinoceptors by inhibiting acetylcholinesterase
Ref :- Book : Basic & Clinical pharmacology Page : 106 Edition : 12.
Mechanism of Action
Mechanism of Action :
Acetylcholinesterase is the primary target of these drugs, but butyrylcholinesterase is also inhibited. All the cholinesterase inhibitors increase the concentration of endogenous acetylcholine at cholinoceptors by inhibiting acetylcholinesterase
Book : Basic & Clinical pharmacology Page : 106 Edition : 12.
Pathway of DIETARY Product
► Act.Comp / Nutrient / Food / Herb as follows :- Black current with same pathway.
► URL --
DIETARY Substance Interactions
► This Medicine interact with :- NA
ContraIndication DIETARY Substance
► This Medicine contraindicate with :- NA
► Route of Elimination :
Renal
Ref :- Book : Goodman Page : 247 Edition : 12.
Route of Elimination
Route of Elimination :
Renal
Book : Goodman Page : 247 Edition : 12.
► Plasma Half-life :
Min value :- NA
Max value :- NA
Plasma Half-life
Plasma Half-life :
Min value :- NA
Max value :- NA
► Peak Plasma Concentration :
Min value :- NA
Max value :- NA
Peak Plasma Concentration
Peak Plasma Concentration :
Min value :- NA
Max value :- NA
