Efavirenz is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 964   Edition : 37,

  ►   Brandname : Efavir,Sustiva,Stocrin

  ►  Strength : Capsule with 50  mg, Capsule with 100  mg, Capsule with 200  Mg, Tablet with 600  mg, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12, Martindale    Page : 963   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 963   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 600 mg Capsule o.d. Dose: Given on an empty stomach.
2 HIV infection Oral 600 mg Tablet o.d. Dose: Given on an empty stomach.
3 AIDS Oral 600 mg Capsule o.d. Dose: Given on an empty stomach.
4 AIDS Oral 600 mg Tablet o.d. Dose: Given on an empty stomach.
5 HIV infection Oral 720 mg Solution o.d.
6 AIDS Oral 720 mg Solution o.d.

Ref :-  Book : Martindale    Page : 963   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection 3 year of age and older 10 to 14 kg Oral 200 mg Capsule o.d.
2 HIV infection 3 years of age and older 10 to 14 kg Oral 200 mg Tablet o.d.
3 HIV infection 3 Year of age and older 15 to 19 kg Oral 250 mg Capsule o.d.
4 HIV infection 3 years of age and older 15 to 19 kg Oral 250 mg Tablet o.d.
5 HIV infection 3 Year of age and older 20 to 24 kg Oral 300 mg Capsule o.d.
6 HIV infection 3 years of age and older 20 to 24 kg Oral 300 mg Tablet o.d.
7 HIV infection 3 Year of age and older 25 to 32.4 kg Oral 350 mg Capsule o.d.
8 HIV infection 3 Year of age and older 25 to 32.4 kg Oral 350 mg Tablet o.d.
9 HIV infection 3 Year of age and older 32.5 to 39 kg Oral 400 mg Capsule o.d.
10 HIV infection 3 Year of age and older 32.5 to 39 kg Oral 400 mg Tablet o.d.
11 HIV infection 10 to 14 kg Oral 200 mg Capsule o.d.
12 HIV infection 10 to 14 kg Oral 200 mg Tablet o.d.
13 HIV infection 15 to 19 kg Oral 250 mg Capsule o.d.
14 HIV infection 15 to 19 kg Oral 250 mg Tablet o.d.
15 HIV infection 20 to 24 kg Oral 300 mg Capsule o.d.
16 HIV infection 20 to 24 kg Oral 300 mg Tablet o.d.
17 HIV infection 25 to 32.4 kg Oral 350 mg Capsule o.d.
18 HIV infection 25 to 32.4 kg Oral 350 mg Tablet o.d.
19 HIV infection 32.5 to 39 kg Oral 400 mg Capsule o.d.
20 HIV infection 32.5 to 39 kg Oral 400 mg Tablet o.d.
21 HIV infection Less than 5Year 13-14 kg Oral 360 mg Solution
22 HIV infection 5 year and older 13 to 14 kg Oral 270 mg Solution o.d.
23 HIV infection Less than 5Year 15 to 19 kg Oral 390 mg Solution
24 HIV infection 5 year and older 15 to 19 kg Oral 300 mg Solution o.d.
25 HIV infection Less than 5 Year 20 to 24 kg Oral 450 mg Solution
26 HIV infection 5 years and older 20 to 24 kg Oral 360 mg Solution o.d.
27 HIV infection Less than 5Year 25 to 32.4 kg Oral 510 mg Solution
28 HIV infection 5 years and older 25 to 32.4 kg Oral 450 mg Solution o.d.
29 HIV infection 5 year and older 32.5 to 39 kg Oral 510 mg Solution o.d.
30 HIV infection 5 year and older 40 kg or more Oral 720 mg Solution
31 HIV infection 40 kg or more Oral 600 mg Tablet o.d.
32 HIV infection 40 kg or more Oral 600 mg Capsule o.d.

Ref :- Book : Martindale    Page : 964   Edition : 37,
►  Side Effect : Skin rashes, CNS disturbances, Psychiatric disturbances, maculopapular, erythema multiforme, Stevens-Johnson syndrome, agitation, amnesia, Confusion, Dizziness, euphoria, headache, insomnia, Somnolence, impaired concentration, impaired concentration, Abnormal thinking, Abnormal dreaming, convulsion, depersonalisation, Severe depression, suicidal ideation, aggressive behaviour, psychotic reactions, psychotic reactions, Paranoia, mania, nausea, vomiting, diarrhea, diarrhoea, fatigue, Pancreatitis, raised liver enzyme values, raised liver enzyme values, Raised serum cholesterol concentration, Raised serum cholesterol concentration, Raised triglycerides concentration, hepatic failure, photoallergic dermatitis, Immune reconstitution syndrome, central obesity, dorsocervical fat enlargement , peripheral wasting, facial wasting, breast enlargement, cushingoid appearance, cushingoid appearance, hyperglyceridemia, hypercholesterolaemia, insulin resistance, Hyperglycaemia, Hyperlactataemia,
Ref :-   Book : Martindale    Page : 963   Edition : 37,

►  Drug Interaction : Drug interaction of Efavirenz is with , ,  Astemizole, Terfenadine, Bepridil, dihydroergotamine, Ergometrine , Ergotamine, Methylergometrine, Cisapride , Pimozide , Midazolam , Triazolam ,
Ref :-   Book : Martindale    Page : 963   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Efavirenz is metabolised mainly by cytochrome P450 isoenzymes including CYP3A4. Consequently, it may compete with other drugs metabolised by this system, potentially resulting in mutually increased plasma concentrations and toxicity. Enzyme inducers may decrease plasma concentrations of efavirenz; efavirenz itself acts as an enzyme inducer and can reduce plasma concentrations of other drugs. Efavirenz is contra-indicated with drugs that are highly dependent on CYP3A4 for clearance and for which elevated plasma concentrations are associated with serious or life-threatening events. These drugs include antihistamines (astemizole and terfenadine), calciumchannel blockers (bepridil), ergot derivatives (dihydroergotamine, ergometrine, ergotamine, methylergometrine), gastrointestinal prokinetics (cisapride), antipsychotics (pimozide), and sedatives and hypnotics (midazolam and triazolam). St John’s wort decreases the concentration of efavirenz; use with the antiretroviral is not recommended due to the possible loss of its activity and development of resistance.,
Ref :-   Book : Martindale    Page : 963   Edition : 37,


►  Contraindication : Severe hepatic impairment, Mild to moderate liver disease, History of seizures, psychiatric disorder, depression, Efavirenz should be stopped if a severe skin rash, associated with blistering, desquamation, mucosal involvement, or fever, develops,
Ref :-   Book : Martindale    Page : 963   Edition : 37,
  ►  Mechanism of Action :   The nonnucleoside reverse transcriptase inhibitor bind directly to HIV-1 reverse transcriptase resulting in allosteric inhibition of RNA and DNA dependent DNA polymerase activity.,
Ref :-   Book : Martindale    Page : 963   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Castarospermum austrate i.e. Mareton bay Chestnut with Another pathway,

  ►  Pathway with its reference as follows :-
  • Castarospermine have Anti HIV activity. --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 963   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   40 hours,    Max value :-   55 hours,
    Ref :-   Book : Martindale    Page : 963   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 963   Edition : 37,