Eflornithine is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book : Martindale    Page : 920   Edition : 37  

  ►   Brandname : Ornidyl, Vaniqa
  ►  Strength : Injection with 200 mg/ml.  Cream with 15 %. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12   Martindale    Page : 920   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Topical
Reference :-   Book : Martindale    Page : 919   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 African trypanosomiasis IV infusion 100 mg/kg Injection Dose: Given every 6 hours for at least 14 days.
2 Reduction in unwanted facial hair in women Topical 15 % Cream

Ref :-  Book : Martindale    Page : 919-920   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Trypanosoma brucei gambiense infection 400 mg/kg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1176   Edition : 19  
►  Side Effect : Myelosuppression, Anaemia, leucopenia, Thrombocytopenia, Skin irritant, Erythema, Stinging, Burning sensation, Hearing loss, Alopecia, Diarrhea, Seizure, Acne
Ref :-   Book : Martindale    Page : 919   Edition : 37.  

►  Drug Interaction : Drug interaction of Eflornithine is with NA

  ►    Mechanism of Drug Drug Interaction : 
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : Renal impairment
Ref :-   Book : Martindale    Page : 919   Edition : 37.  
  ►  Mechanism of Action :   Eflornithine is an antiprotozoal that acts as an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. It inhibits protozoal DNA synthesis. Ref: Clinical Pharmacology pg no 275 ed 9.
Ref :-   Book : Martindale    Page : 919   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 919   Edition : 37.  

►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 919   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA