Enoxaparin sodium is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1407   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Lovenox,Clexane,Enclex

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1407   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IV,
Reference :-   Book : Martindale    Page : 1407   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of venous thromboembolism SC 20 mg Injection o.d. Dose: Patients at low to moderate risk; Given (2000 units) with the first dose about 2 hours pre-operatively.
2 Prophylaxis of venous thromboembolism (In patients at high risk) SC 40 mg Injection o.d. Dose: Given (4000 unit) with the initial dose given about 12 hours before the procedure.
3 Prophylaxis of thromboembolism in immobilised medical patients SC 40 mg Injection o.d. Dose: Given (4000 unit) daily for at least 6 days; treatment should be continued until the patient is fully ambulant, up to a maximum of 14 days.
4 Deep-vein thrombosis SC 1 mg/kg Injection Dose: (100 units/kg) every 12 hours, or 1.5 mg/kg (150 units/kg) once daily, for at least 5 days and until oral anticoagulation is established.
5 Haemodialysis SC 1 mg/kg Injection Dose: (100 units/kg) is introduced into the arterial line of the circuit at the beginning of the dialysis session.
6 unstable angina SC 1 mg/kg Injection Dose: (100 units/kg) every 12 hours. Treatment is usually continued for 2 to 8 days.
7 ST-elevation myocardial infarction SC 30 mg Injection Dose: (3000 units) intravenously, with a subcutaneous dose of 1 mg/kg (100 units/kg) given at the same time.

Ref :-  Book : Martindale    Page : 1406   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Treatment of thromboembolism 2 month of age SC 1.5 mg/kg Injection
2 Treatment of thromboembolism 2 month of age SC 1 mg/kg Injection
3 Prophylaxis of thromboembolism 2 month of age SC 750 micrograms/kg Injection
4 Prophylaxis of thromboembolism 2 month of age SC 500 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1407   Edition : 37,
Precaution :- If a Patient is using 'Enoxaparin sodium' drug in acute kidney injury disease, then Please dose modification needed   if he ever suffered from acute myocardial infarction disease.
►  Side Effect : Haemorrhage, thrombocytopenia, hypersensitivity reactions, skin necrosis, alopecia, osteoporosis, spontaneous fracture,
Ref :-   Book : Martindale    Page : 1406, 1431, 1461   Edition : 37,

►  Drug Interaction : Drug interaction of Enoxaparin sodium is with NSAIDS, , PENICILLINS , , , , ,  Aspirin, Dipyridamole , Dextran, Aspirin, epoprostenol, Drotavereine,
Ref :-   Book : Martindale    Page : 1407,1433,1461   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  It should be used with care with oral anticoagulants or drugs, such as aspirin and dipyridamole, that affect platelet function. NSAIDs may also increase the risk of haemorrhage. Other drugs that affect the coagulation process and which may therefore increase the risk of haemorrhage include dextrans, thrombolytic enzymes such as streptokinase, high doses of penicillins and some cephalosporins, some contrast media, asparaginase, and epoprostenol; for use of heparin with drotrecogin alfa (activated) Estimations of oral anticoagulant control may be modified by heparin’s action on prothrombin.,
Ref :-   Book : Martindale    Page : 1407,1433,1461   Edition : 37,


►  Contraindication : Head injury, Heparin-induced thrombocytopenia, Hypersensitivity, renal insufficiency, peptic ulcer disease, cerebrovascular disorder, bacterial endocarditis, severe hypertension, oesophageal varices, Severe hepatic impairment, haemorrhagic blood disorder,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 398   Edition : 3, Martindale    Page : 1407,1433,1461   Edition : 37,
  ►  Mechanism of Action :   Combine with antithrombin III and inhibit secondary homeostatis via relatively (threefold) selective invitation of factor Xa.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 397   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Witch hazel with Another pathway,

  ►  Pathway with its reference as follows :-
  • Tannins, Volatile Oil have Anti-coagulant Property. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1406   Edition : 37, Martindale    Page : 1407   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   4 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 1406   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 1406   Edition : 37,