Entecavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 966   Edition : 37,

  ►   Brandname : Baraclude

  ►  Strength : Tablet with 0.5  mg, Tablet with 1  Mg, Oral solution with 0.05  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic hepatitis B Oral 500 micrograms Tablet o.d. Dose: usual oral dose of entecavir in nucleoside treatment-naive patients; Given either with or without food.
2 Chronic hepatitis B Oral 1 mg Tablet o.d. Dose: Given on an empty stomach should be used in patients with a history of hepatitis B viraemia during lamivudine therapy or with known resistance to lamivudine.

Ref :-  Book : Martindale    Page : 966   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : headache, fatigue, Dizziness, nausea, diarrhea, dyspepsia, insomnia, Somnolence, vomiting, Raised liver enzyme concentrations, Exacerbation of hepatitis B has been reported both during and after stopping treatment with entecavir, Lactic acidosis, usually associated with severe hepatomegaly and steatosis,
Ref :-   Book : Martindale    Page : 965   Edition : 37,

►  Drug Interaction : Drug interaction of Entecavir is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Hypersensitivity, hepatomegaly, Other risk factors for liver disease, renal impairment, Hepatic function should be monitored closely while on treatment and for several months after treatment is stopped.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 671   Edition : 3, Martindale    Page : 965   Edition : 37,
  ►  Mechanism of Action :   The anti-HIV nucleoside analogues are phosphorylated by cellular kinases, and then inhibit viral reverse transcriptase. Anti-HBV nucleoside analogues are also phosphorylated by cellular enzymes, and then inhibit HBV polymerase.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 671   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with ,

  ►  Pathway with its reference as follows :-
  • Turmeric having active compound curcumin which act as antiviral . --- (Zorofchian Moghadamtousi, S., Abdul Kadir, H., Hassandarvish, P., Tajik, H., Abubakar, S., & Zandi, K. (2014). A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin. Biomed Research International, 2014, 1-12. http://dx.doi.org/10.1155/2014/186864 )

  •   ►  URL -- https://www.hindawi.com/journals/bmri/2014/186864/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 966   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   128 hours,    Max value :-   149 hours,
    Ref :-   Book : Martindale    Page : 966   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   30 minutes,    Max value :-   90 minutes,
    Ref :-   Book : Martindale    Page : 966   Edition : 37,