Ephedrine is a Medicine belongs to sympathomimetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1699   Edition : 37,

  ►   Brandname : CAM,Kondon’s Nasal

  ►  Strength : Capsule with 25  mg, Injection with 50  mg/ml, Elixir with   , Tablet with   , Nasal Drop with   , Nasal solution with   , Syrup with   , Spray with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 355   Edition : 12, Martindale    Page : 1698-1699   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, SC, IM, Oral, Topical,
Reference :-   Book : Martindale    Page : 1698-1699   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypotension slow i.v 3 mg/ml Injection Given in doses of 3 to 6 mg (or at most 9 mg) repeated every 3 to 4 minutes as required; the maximum total dose is 30 mg
2 Diabetic neuropathic oedema Oral 30 60 mg t.i.d.
3 Nasal congestion nasal 0.5 1 % Nasal drops/Nasal sprays

Ref :-  Book : Martindale    Page : 1699   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nasal congestion 6Year 12Year nasal 0.5 % Nasal Drop t.i.d/q.i.d
2 Hypotension 1 Year 12 Year slow i.v 500 750 micrograms/kg Injection
3 Hypotension 1 Year 12 Year slow i.v 17 25 mg/m2 Injection
4 Hypotension 12 Year 18 Year slow i.v 3 7.5 mg Injection

Ref :- Book : Martindale    Page : 1699   Edition : 37,
►  Side Effect : tachycardia, anxiety, Restlessness, insomnia, tremor, dry mouth, impaired circulation to the extremities, hypertension, cardiac arrhythmia, fear, Confusion, irritability, headache, psychotic states, dyspnoea, weakness, anorexia, nausea, vomiting, palpitations, cardiac arrest, angina, Increase in cardiac contractility,
Ref :-   Book : Martindale    Page : 1544,1698   Edition : 37,

►  Drug Interaction : Drug interaction of Ephedrine is with , , Cardiac Glycosides, Tricyclic antidepressant , ,  Halothane , Quinidine , Oxytocin ,
Ref :-   Book : Martindale    Page : 449,1698   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Ephedrine has direct and indirect actions and may cause a hypertensive crisis in patients receiving an MAOI. Severe hypertensive reactions due to enhancement of pressor activity have followed the use of sympathomimetics such as ephedrine. Since ephedrine has both alpha- and beta-agonist properties it should be avoided or used with care in patients undergoing anaesthesia with cyclopropane, halothane, or other volatile anaesthetics. An increased risk of arrhythmias may occur if given to patients receiving cardiac glycosides, quinidine, or tricyclic antidepressants, and there is an increased risk of vasoconstrictor or pressor effects in patients receiving ergot alkaloids or oxytocin. The rate of metabolism of some other drugs is increased by ephedrine.,
Ref :-   Book : Martindale    Page : 449,1698   Edition : 37,


►  Contraindication : hyperthyroidism, Diabetes mellitus, ischaemic heart disease, hypertension, renal impairment,
Ref :-   Book : Martindale    Page : 1698   Edition : 37,
  ►  Mechanism of Action :   Ephedrine is a sympathomimetic with direct and indirect effects on adrenergic receptors. It has alpha- and beta-adrenergic activity and has pronounced stimulating effects on the CNS. It has a more prolonged though less potent action than adrenaline. In therapeutic doses it raises the blood pressure by increasing cardiac output and also by inducing peripheral vasoconstriction. Tachycardia may occur but is less frequent than with adrenaline. Ephedrine also causes bronchodilatation, reduces intestinal tone and motility, relaxes the bladder wall while contracting the sphincter muscle but relaxes the detrusor muscle of the bladder and usually reduces the activity of the uterus.,
Ref :-   Book : Martindale    Page : 1698   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with It cause anxiety , confusion & other side effect ., EPHEDRA with Avoid ephedra herb with this drug to prevent potentially serious interactions ., BLACK TEA with contain tannin it may interfer with the absorption ., WITCH HAZEL with Containing high amount of tannins which may interfere with the absorption of atropine taken by mouth ., MAKANDI with It should not be combined with ephedrine because it raising the doses of the drug as they lose effectiveness ., COFFEE with It contains caffeine which can amplify the side effects of drug .,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1698   Edition : 37,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : `1698   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,