Epirubicin is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 784   Edition : 37  

  ►   Brandname : Ellence, Pharmorubicin, Epi-Cell, Epi-NC, Farmorubicin, Riboepi
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 784   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 784   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antineoplastic IV 60 90 mg/m2 Injection Dose: Given as as a single agent in usual dose every 3 weeks; this dose may be divided over 2 or 3 days if desired.
2 Bladder cancer intravesical instillation 50 mg Injection Dose: Given weekly as a 0.1% solution (in sodium chloride 0.9% or sterile water) for 8 weeks has been suggested, reduced to 30 mg in 50 mL weekly if chemical cystitis develops; for carcinoma in-situ, the dose may be increased, if tolerated, to 80 mg in 50 mL weekly.

Ref :-  Book : Martindale    Page : 784   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Mucositis, Alopecia, Mucositis, Alopecia, Gastrointestinal disturbance, Nausea, Vomiting, Bone marrow depression, ECG abnormalities, Stomatitis, Oesophagitis, Haemorrhagic cystitis, Facial flushing, Conjunctivitis, Transient disturbance of cardiac function, Severe cardiotoxicity, Occasional hypersensitivity, Lacrimation, Local necrosis, Ulceration, Urethral irritation, Haematuria, Hyperuricaemia, Hyperpigmentation of the oral mucosa and/ or nails, Onycholysis, Onycholysis, Drowsiness, Renal damage, Hepatic damage, Transient increases in liver enzymes, Thrombophlebitis
Ref :-   Book : Martindale    Page : 780,784   Edition : 37.  

►  Drug Interaction : Drug interaction of Epirubicin is with Live Vaccines,  Daunorubicin (Daunomycin), Cyclopentolate , Cyclophosphamide , Stavudine, Lincomycin
Ref :-   Book : Martindale    Page : 698,781,784   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  The cumulative dose of Epirubicin should be reduced in patients who have received other cardiotoxic drugs such as daunorubicin or cyclophosphamide. Epirubicin is reported to inhibit the intracellular activation of stavudine and hence its antiviral effect. antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines possibility of generalized infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted.
Ref :-   Book : Martindale    Page : 698,781,784   Edition : 37.  

►  Contraindication : Cardiac disease, Hepatic impairment, Breast feeding, Great caution is needed when the marrow is already depressed from radiotherapy or therapy with other antineoplastics, and modification of dosage regimens may be required
Ref :-   Book : Martindale    Page : 697,781,784   Edition : 37.  
  ►  Mechanism of Action :   Epirubicin is an anthracycline antibiotic with antineoplastic. It is thought to have multiple modes of action including intercalation of DNA leading to an inhibition of DNA and RNA synthesis, inhibition of topoisomerase II, free radical formation, and alterations in cell membranes. Epirubicin is a cell-cycle non-specific agent
Ref :-   Book : Martindale    Page : 782,784   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Vincristine and vinblastine arrests multiplication of cancerous cells --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary
    Ref :-   Book : Martindale    Page : 784   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   30 hours,    Max value :-   40 hours.  
    Ref :-   Book : Martindale    Page : 784   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .