Eplerenone is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1408   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Inspra,Eptus

  ►  Strength : Tablet with 25  mg, Tablet with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 225   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1408   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 50 mg Tablet Dose: Given daily, increasing if necessary to a maximum of 50 mg twice daily. While eplerenone should not be given with potent CYP3A4 inhibitors, patients taking mild to moderate inhibitors may be given eplerenone; the initial dose should be reduced to 25 mg daily.
2 Heart failure after myocardial infarction Oral 25 mg Tablet Dose: Given daily, increasing to 50 mg daily within 4 weeks if tolerated. Eplerenone should be withdrawn or the dose should be reduced to 25 mg daily, or on alternate days, if hyperkalaemia develops.

Ref :-  Book : Martindale    Page : 1408   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : headache, drowsiness, gastrointestinal disturbance, cramp, diarrhea, ataxia, mental confusion, Rashes, Gynaecomastia, breast enlargement, Hirsutism, deepening of the voice, menstrual irregularities, acidosis, hyponatraemia, hyperkalaemia, ,
Ref :-   Book : Martindale    Page : 1408,1536   Edition : 37,

►  Drug Interaction : Drug interaction of Eplerenone is with , , Angiotensin converting enzyme inhibitor, Angiotensin II Receptor Antagonist, NSAIDS, , ,  Cidofovir , Trilostane, Chlorpropamide , Carbimazole , Noradrenaline/Norepinephrine ,
Ref :-   Book : Martindale    Page : 1408,1537   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of hyperkalaemia if eplerenone is given with potassium supplements or with other potassium-sparing diuretics. Hyperkalaemia may occur as well in patients also given ACE inhibitors, angiotensin II receptor antagonists, NSAIDs, ciclosporin, or trilostane. In patients given eplerenone with NSAIDs or ciclosporin the risk of nephrotoxicity may also be increased. Diuretics may reduce the excretion of lithium and increase the risk of lithium toxicity. Hyponatraemia may occur in patients taking a potassium-sparing diuretic with a thiazide; this risk may be increased in patients given chlorpropamide. Eplerenone may reduce the ulcer-healing properties of carbenoxolone. As with other diuretics, eplerenone may enhance the effects of other antihypertensive drugs and may reduce vascular responses to noradrenaline.,
Ref :-   Book : Martindale    Page : 1408,1537   Edition : 37,


►  Contraindication : acute renal insufficiency, Anuria, hyperkalemia,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 352   Edition : 3,
  ►  Mechanism of Action :   Inhibit aldosetrone action by binding to and preventing nuclear translocation of the minralocorticoid receptor. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 352   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FRANGULA I.E. RHAMNUS FRANGULA with frangula interact with carticosteroid .,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1408   Edition : 37,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 1408   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1408   Edition : 37,