Epoetin alfa is a Medicine belongs to Erythrocytes-stimulating agent group whose information about Brand can be referenced from   Book : Martindale    Page : 1173   Edition : 37      Page :   Edition :   

  ►   Brandname : Absemed; Espo, Binocrit, Dynepo, Eprex, NeoRecormon, Retacrit, Epogen, Procrit, Eposis
  ►  Strength : Injection with 2000 IU/ml.  Injection with 3000 IU/ml.  Injection with 4000 IU/ml.  Injection with 10000 IU/ml.  Injection with 20000 IU/ml.  Injection with 40000 IU/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 598   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, SC
Reference :-   Book : Martindale    Page : 1172   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaemia of chronic renal failure SC 50 IU/kg Injection t.i.w. Dose: For predialysis and haemodialysis patients, For epoetin alfa, a higher initial dose of 50 to 100 units/kg three times weekly
2 Non-myeloid malignant disease 150 units/kg Injection t.i.w.
3 Non-myeloid malignant disease 450 units/kg Injection QWK
4 HIV-positive patients SC 100 units/kg Injection t.i.w. Dose: on zidovudine therapy for 8 weeks
5 HIV-positive patients IV 100 units/kg Injection t.i.w. Dose: on zidovudine therapy for 8 weeks
6 Mild to moderate anaemia IV 600 units/kg Injection bis in 7 d. Dose: starting 3 weeks before surgery. To increase the yield of autologous blood for transfusion, epoetin alfa, beta, or zeta may be used with iron supplementation in patients with mild to moderate anaemia (haemoglobin 10 to13 g per 100 mL or haematocrit 33 to 39%).

Ref :-  Book : Martindale    Page : 1171-1172   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Anaemia of chronic renal failure IV 50 units/kg Injection t.i.w.
2 Non-myeloid malignant disease IV 600 units/kg Injection QWK

Ref :- Book : Martindale    Page : 1172   Edition : 37  
►  Side Effect : Fever, Chills, Headache, Arthralgia, Myalgia, Asthenia, Dizziness, Tiredness, Rashes, Urticaria, Nausea, Vomiting, Diarrhea, Hyperkalaemia, Pure red cell aplasia, Hypertension, Hypertensive crisis, Encephalopathy, Seizure, Myocardial ischaemia, Transient ischaemic attacks, Cerebrovascular accident, Deep vien thrombosis, Hypersensitivity reactions, Pulmonary embolism, Shunt thromboses
Ref :-   Book : Martindale    Page : 1169   Edition : 37.  

►  Drug Interaction : Drug interaction of Epoetin alfa is with NA

  ►    Mechanism of Drug Drug Interaction : 
Ref :-   Book :    Page :    Edition : .  

►  Contraindication : Hypertension, History of seizures, Thrombocytosis, Chronic hepatic impairment, Ischaemic vascular disease, Patients with malignant tumours, Pure red cell aplasia, Response to epoetins may be diminished by iron deficiency, folic acid and vitamin B12 deficiencies, infection or inflammatory disorders, haemolysis, or aluminium intoxication
Ref :-   Book : Martindale    Page : 1170   Edition : 37.  
  ►  Mechanism of Action :   Erythropoietin is a glycosylated protein hormone and a haematopoietic growth factor. It is secreted primarily by the kidneys, although a small amount is produced in extrarenal sites such as the liver. Erythropoietin regulates erythropoiesis by stimulating the differentiation and proliferation of erythroid precursors, the release of reticulocytes into the circulation, and the synthesis of cellular haemoglobin.
Ref :-   Book : Martindale    Page : 1171   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA