Ergometrine is a Medicine belongs to Obstetric Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2172   Edition : 37  

  ►   Brandname : Ergotrate
  ►  Strength : Tablet with .  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2172   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, sublingual
Reference :-   Book : Martindale    Page : 2172   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Active management of the third stage of labour IM 500 micrograms Injection Dose: Given with oxytocin 5 units is injected intramuscularly after delivery of the anterior shoulder, or, at the latest, immediately after delivery of the infant; contractions are reported to occur within 2 to 7 minutes.
2 Postpartum haemorrhage IM 200 500 micrograms Injection
3 Postpartum haemorrhage IV 250 500 micrograms Injection Dose: In emergencies such as excessive uterine bleeding, Intravenous doses should be given over at least 1 minute to reduce the risk of adverse effects, particularly hypertension.
4 Postpartum haemorrhage IM 200 micrograms Injection Dose: used for prevention or treatment of postpartum or postabortal haemorrhage.
5 Postpartum haemorrhage Oral 200 400 Microgram Tablet b.d/q.i.d Dose: 2 to 4 times daily until the danger of atony and haemorrhage has passed, which is usually 48 hours.

Ref :-  Book : Martindale    Page : 2172   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Nausea, Vomiting, Abdominal pain, Diarrhea, Headache, Dizziness, Tinnitus, chest pain, palpitations, Bradycardia, Cardiac arrhythmia, Coronary artery vasospasm, Myocardial infraction, Dyspnoea, Pulmonary oedema, Hypersensitivity reactions, Shock, Hypertension, Gangrene
Ref :-   Book : Martindale    Page : 2171   Edition : 37.  

►  Drug Interaction : Drug interaction of Ergometrine is with , Beta Blockers , Azole Antifungal, Macrolide, ,  Clarithromycin , Erythromycin , Indinavir, Ritonavir, Rizatriptan , Sumatriptan , Zolmitriptan , Eletriptan , Frovatriptan , Naratriptan , Halothane
Ref :-   Book : Martindale    Page : 675,2172   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  The vasoconstrictor effects of ergotamine are enhanced by sympathomimetics such as adrenaline. There is also an increased risk of peripheral vasoconstriction during use of ergometrine with beta blockers. Ergometrine is metabolised by the cytochrome P450 isoenzyme CYP3A4 and consequently it should not be given with potent inhibitors of this isoenzyme; elevated ergometrine concentrations sufficient to cause ergotism may occur with azole antifungals, macrolide antibacterials such as erythromycin and clarithromycin, and HIV-protease inhibitors including indinavir and ritonavir. Use of tetracycline with ergometrine may also increase the risk of ergotism and should be avoided. Ergometrine should not be used with or given until several hours after stopping a serotonin (5-HT1) agonist, since there is an additional risk of prolonged vasospastic reactions; at least 6 hours is advised for almotriptan, rizatriptan, sumatriptan, and zolmitriptan, and at least 24 hours for eletriptan and frovatriptan. Conversely, a delay is advised before starting a serotonin agonist in patients who have been receiving ergotamine: almotriptan, eletriptan, frovatriptan, rizatriptan, sumatriptan, or zolmitriptan should not be given until at least 24 hours after stopping the use of preparations containing ergometrine. Halothane has been considered to diminish the effects of ergometrine on the uterus.
Ref :-   Book : Martindale    Page : 675,2172   Edition : 37.  

►  Contraindication : Veno-atrial shunts, Mitral valve stenosis, Ergometrine is contraindicated for the induction of labour or for use during the first stage of labour. If used at the end of the second stage of labour, before delivery of the placenta, there must be expert obstetric supervision., Its use should be avoided in patients with pre-eclampsia, eclampsia, or threatened spontaneous abortion.
Ref :-   Book : Martindale    Page : 2172   Edition : 37.  
  ►  Mechanism of Action :   Ergometrine has a much more powerful action on the uterus than most other ergot alkaloids, especially on the puerperal uterus. Its main action is the production of intense contractions, which at higher doses are sustained, in contrast to the more physiological rhythmic uterine contractions induced by oxytocin; its action is more prolonged than that of oxytocin
Ref :-   Book : Martindale    Page : 2172   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ergot with same compound.  

  ►  Pathway with its reference as follows :-
  • It is ergot alkaloids vasoconstriction by stimulation of alpha-adrenergic and serotonin receptors and inhibition of endothelial-derived relaxation factor release --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 2172   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA