Erythromycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 297   Edition : 37, Martindale    Page : 292   Edition : 37,

  ►   Brandname : E-Mycin, EES, Eryacne, Eryc, Eryhexal, Akne Cordes, Aknederm Ery, Aknefug-EL, Acnesol, Althrocin, Calthrox, E-Mycin, Eltocin, Erycin, Akne-Mycin, ATS, Del-Mycin, Erymax, Erythrocin, Erythroped, Rommix

  ►  Strength : Tablet (Enteric Coated) with 250  mg, Tablet (Enteric Coated) with 333  mg, Tablet (Enteric Coated) with 500  mg, Delayed-release capsules with 250  mg, Tablet with 500  mg, Tablet with 400  mg, Suspension with 125  mg/5mL, Suspension with 250  mg/5mL, Suspension with 200  mg/5mL, Suspension with 400  mg/5mL, Tablets (film-coated) with 250  mg, Tablets (film-coated) with 500  mg, Injection with 0.5  gm, Injection with 1  gm, Gel/Solution with 2  %, Gel/Solution with 4  %, Eye ointment with 0.5  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12, Martindale    Page : 297   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV,
Reference :-   Book : Martindale    Page : 297   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Streptococcal infections Oral 250 mg b.d. Dose: in patients with evidence of rheumatic fever or heart disease, who are unable to take penicillin or sulfonamides.
2 Acne 250 mg Dose: maintenance doses, given daily.
3 Superficial ocular infections ophthalmic 0.5 % Eye ointment including neonatal conjunctivitis, caused by susceptible strains of bacteria and for the prophylaxis of neonatal conjunctivitis caused by N. gonorrhoeae or C. trachomatis.
4 Acne vulgaris Topical 2 4 % Gel/Solution It is also available in combination preparations with benzoyl peroxide, ichthammol, isotretinoin, tretinoin, and zinc acetate.

Ref :-  Book : Martindale    Page : 296   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by susceptible organisms Oral 30 50 mg/kg
2 Infections caused by susceptible organisms Continuous or intermittent intravenous infusion 30 50 mg/kg Injection
3 Infections caused by susceptible organisms Oral 12.5 mg/kg
4 Infections caused by susceptible organisms IV 10 12.5 mg/kg Injection
5 Infections caused by susceptible organisms 1 Week Less than 1.2 kg at birth Oral 10 mg/kg
6 Infections caused by susceptible organisms 1.2 kg or more Oral 10 mg/kg
7 Prevention of recurrence of rheumatic fever 1 Month 2 Year Oral 125 mg b.d.
8 Prevention of secondary cases of group A streptococcal infection 1 Month 2 Year 125 mg
9 Prevention of secondary cases of group A streptococcal infection 2 Year 8 Year Oral 250 mg
10 Prevention of secondary cases of group A streptococcal infection 8 Year Oral 250 500 mg
11 Prevention of secondary cases of diphtheria or pertussis 1 Month 2 Year Oral 125 mg
12 Prevention of secondary cases of diphtheria or pertussis 2 Year 8 Year Oral 250 mg
13 Prevention of secondary cases of diphtheria or pertussis 8 Year Oral
14 Acne 12 Year Oral 500 mg o.d.
15 Acne Oral 250 mg
16 Gastrointrestinal stasis 3 mg/kg QWK

Ref :- Book : Martindale    Page : 296-297   Edition : 37,
Precaution :- If a Patient is using 'Erythromycin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Erythromycin' drug in  Cholestasis  disease, then Please hepatotoxic. increased risk of xanthomas .

►  Side Effect : gastrointestinal disturbance, abdominal discomfort, cramp, nausea, vomiting, diarrhoea, Pseudomembranous colitis, hypersensitivity reactions, pruritus, Urticaria, Skin rashes, anaphylaxis, Hypersensitivity may occur after topical application, Irritation may occur after topical application, cholestasis, jaundice, Rashes, fever, eosinophilia, agranulocytosis, Pancreatitis, QT interval prolongation, torsade de pointes, Confusion, hallucinations, seizures, vertigo, Upper abdominal pain, Abnormal liver function values, Aggravation of muscular weakness in myasthenia gravis patients, ,
Ref :-   Book : Martindale    Page : 293-294   Edition : 37,

►  Drug Interaction : Drug interaction of Erythromycin is with Astemizole, Cisapride , Terfenadine, Spiramycin , Levodopa , Theophylline ,
Ref :-   Book : Martindale    Page : 295   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Erythromycin and other macrolides have the potential to interact with a large number of drugs through their action on hepatic cytochrome P450 isoenzymes, particularly CYP1A2 and CYP3A4. Macrolides inhibit drug metabolism by microsomal cytochromes by competitive inhibition and by the formation of inactive complexes. Such interactions can result in severe adverse effects, including ventricular arrhythmias with them. Macrolides-induced inhibition of metabolism can result in severe adverse effects, including ventricular arrhythmia with astemazole, cisapride, and terfenadine. Other mechanisms by which macrolides cause interactions include suppression of the gastrointestinal flora responsible for the intraluminal metabolism of digoxin and possibly oral contraceptives, and the stimulant effect of macrolides on gastrointestinal motility which is believed to be responsible for the interaction between spiramycin and levodopa. An alternative mechanism by which macrolides increase serum concentrations of digoxin is thought to be via the inhibition of intestinal or renal P-glycoprotein transport of digoxin.Few drugs are reported to affect erythromycin but cimetidine may increase and theophylline may decrease erythromycin concentrations.,
Ref :-   Book : Martindale    Page : 295   Edition : 37,


►  Contraindication : renal impairment, It should be avoided in those known to be hypersensitive to it, or in those who have previously developed jaundice., It may aggravate muscle weakness in patients with myasthenia gravis, It should be used with care in patients with a history of arrhythmias or a predisposition to QT interval prolongation., It is irritant; solutions for parenteral use should be suitably diluted and given by intravenous infusion over 20 to 60 minutes to reduce the incidence of thrombophlebitis. Rapid infusion is also more likely to be associated with arrhythmias or hypotension,
Ref :-   Book : Martindale    Page : 294   Edition : 37,
  ►  Mechanism of Action :   It is a bacteriostatic agent that inhibit protein synthesis by binding reversibly to 50S ribosomal subunits of sensitive microorganisms, at or very near the site that binds chloramphenicol.,
Ref :-   Book : Goodman    Page : 1530   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • have Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B6 with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level, BROMELAIN with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FRUIT JUICES with fruit juice consumption decreases drug effectiveness.,

      ►  Reference :-
  • "Introduction Food, Dietary Supplements And Their Components Can .". European Journal o f Clinical Pharmacology, n. pag. Print.

  •   ►  URL -- http://shodhganga.inflibnet.ac.in/bitstream/10603/42594/5/05_chapter%201.pdf,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 296   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 296   Edition : 37,