Erythromycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 297   Edition : 37,

  ►   Brandname : Akne Cordes,Aknederm Ery,Aknefug-EL,E-Mycin,Eryacne,Eryc,Eryhexal,Acnesol,Althrocin,Calthrox,E-Mycin,Eltocin,Erymax,Erythrocin,Erythroped,Akne-Mycin,ATS,Del-Mycin,E-Base

  ►  Strength : Tablet (Enteric Coated) with 250  mg, Tablet (Enteric Coated) with 333  mg, Tablet (Enteric Coated) with 500  mg, Capsule with 250  mg, Suspension with 125/5  mg/ml, Suspension with 250/5  mg/ml, Tablet with 250  mg, Tablet with 500  mg, Injection with 0.1  gm, Injection with 1  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV,
Reference :-   Book : Martindale    Page : 292   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Streptococcal infections Oral 250 mg b.d. Dose: in patients with evidence of rheumatic fever or heart disease, who are unable to take penicillin or sulfonamides.
2 Acne 250 mg Dose: maintenance doses, given daily.
3 Superficial ocular infections ophthalmic 0.5 % Eye ointment including neonatal conjunctivitis, caused by susceptible strains of bacteria and for the prophylaxis of neonatal conjunctivitis caused by N. gonorrhoeae or C. trachomatis.
4 Acne vulgaris Topical 2 4 % Gel/Solution It is also available in combination preparations with benzoyl peroxide, ichthammol, isotretinoin, tretinoin, and zinc acetate.

Ref :-  Book : Martindale    Page : 296   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by susceptible organisms Oral 30 50 mg/kg
2 Infections caused by susceptible organisms Continuous or intermittent intravenous infusion 30 50 mg/kg Injection
3 Infections caused by susceptible organisms Oral 12.5 mg/kg
4 Infections caused by susceptible organisms IV 10 12.5 mg/kg Injection
5 Infections caused by susceptible organisms 1 Week Less than 1.2 kg at birth Oral 10 mg/kg
6 Infections caused by susceptible organisms 1.2 kg or more Oral 10 mg/kg
7 Prevention of recurrence of rheumatic fever 1 Month 2 Year Oral 125 mg b.d.
8 Prevention of secondary cases of group A streptococcal infection 1 Month 2 Year 125 mg
9 Prevention of secondary cases of group A streptococcal infection 2 Year 8 Year Oral 250 mg
10 Prevention of secondary cases of group A streptococcal infection 8 Year Oral 250 500 mg
11 Prevention of secondary cases of diphtheria or pertussis 1 Month 2 Year Oral 125 mg
12 Prevention of secondary cases of diphtheria or pertussis 2 Year 8 Year Oral 250 mg
13 Prevention of secondary cases of diphtheria or pertussis 8 Year Oral
14 Acne 12 Year Oral 500 mg o.d.
15 Acne Oral 250 mg
16 Gastrointrestinal stasis 3 mg/kg QWK

Ref :- Book : Martindale    Page : 296-297   Edition : 37,
►  Organ Affected Hepatotoxic (Cholestatic jaundice)  

Precaution :- If a Patient is using 'Erythromycin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Erythromycin' drug in  Cholestasis  disease, then Please hepatotoxic. increased risk of xanthomas .

►  Side Effect : gastrointestinal disturbance, abdominal discomfort, cramp, nausea, vomiting, diarrhoea, Pseudomembranous colitis, hypersensitivity reactions, pruritus, Urticaria, Skin rashes, anaphylaxis, Hypersensitivity may occur after topical application, Irritation may occur after topical application, cholestasis, jaundice, Rashes, fever, eosinophilia, agranulocytosis, Pancreatitis, QT interval prolongation, torsade de pointes, Confusion, hallucinations, seizures, vertigo, Upper abdominal pain, Abnormal liver function values, Aggravation of muscular weakness in myasthenia gravis patients, ,
Ref :-   Book : Martindale    Page : 293-294   Edition : 37,

►  Drug Interaction : Drug interaction of Erythromycin is with oral,  Pimozide , Quinidine , Theophylline , Ropinirole , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) , Carbamazapine , Cisapride , Colchicine , Cyclosporine , digitalis, Acid alpha glucosidase ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1152, 1154, 1155, 1156, 1157, 1158   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Clarithromycin is known to inhibit CYP3A4 and P-glycoprotein (responsible for distribution of drugs) therefore produces following changes: Increased pimozide concentrations. Increased serum quinidine concentrations. Decreased metabolism of theophylline, oral anticoagulant, calcium channel blockers, carbamazepine, cyclosporine, cisapride (possible may cause ventricular arrhythmia). Decreased colchicine metabolism and transport. Digoxin susceptible to alteration of gastrointestinal absorption by macrolides which increases its plasma concentration.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1152-1158   Edition : 12,


►  Absolute Contraindication : Hypersensitivity   or in those who have previously developed jaundice   pregnancy.  

►  Contraindication : Arrhythmia, hepatic impairment, Hypersensitivity, pregnancy, renal impairment,
Ref :-   Book : Martindale    Page : 294   Edition : 37,
  ►  Mechanism of Action :   It is a bacteriostatic agent that inhibit protein synthesis by binding reversibly to 50S ribosomal subunits of sensitive microorganisms, at or very near the site that binds chloramphenicol.,
Ref :-   Book : Goodman    Page : 1530   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • have Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B6 with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level, BROMELAIN with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FRUIT JUICES with fruit juice consumption decreases drug effectiveness.,

      ►  Reference :-
  • "Introduction Food, Dietary Supplements And Their Components Can .". European Journal o f Clinical Pharmacology, n. pag. Print.

  •   ►  URL -- http://shodhganga.inflibnet.ac.in/bitstream/10603/42594/5/05_chapter%201.pdf,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 296   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 296   Edition : 37,