Escitalopram is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 422   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Cipralex,Lexapro,Recita,S-Citadep,Escitalent,Petril Plus,Clonafit Plus

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Tablet with 20  mg, Solution with 5/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 422   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 10 mg Tablet o.d. Dose: increased, after at least a week, to a maximum of 20 mg once daily if necessary.
2 Panic disorders Oral 5 mg Tablet o.d. Dose: increased after a week to 10 mg once daily; further increases up to a maximum of 20 mg daily may be necessary in some patients.

Ref :-  Book : Martindale    Page : 422   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression 12 Year 17 Year Oral 5 20 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 63   Edition : 19,
►  Side Effect : dry mouth, Gastrointestinal disturbances, nausea, vomiting, dyspepsia, constipation, diarrhoea, anorexia, weight loss, anxiety, Restlessness, Nervousness, insomnia, drowsiness, fatigue, headache, tremor, Dizziness, seizures, hallucinations, Confusion, agitation, extrapyramidal effects, depersonalisation, mania, panic attacks, sexual dysfunction, Excessive sweating, pruritus, Rashes, alopecia, photosensitivity, Urticaria, angioedema, Anaphylactoid reactions, hyponatraemia, arthralgia, myalgia, Orthostatic hypotension, yawning, urinary retention, Blurred Vision, mydriasis, systemic hypersensitivity reactions involving the lungs, kidneys, or liver, and possibly related to vasculitis, have developed, Hyperprolactinaemia and galactorrhoea have occurred, as have changes in blood sugar, in patients receiving SSRIs, SSRIs have occasionally been associated with bleeding disorders such as ecchymosis and purpura and other effects on the blood, ,
Ref :-   Book : Martindale    Page : 416,420,422   Edition : 37,

►  Drug Interaction : Drug interaction of Escitalopram is with Monoamine Oxidase Inhibitors,  NA

  ►    Mechanism of Drug Drug Interaction :  SSRIs interact with other drugs mainly as a result of their inhibitory activity on hepatic cytochrome P450 isoenzymes. As SSRIs have occasionally been associated with bleeding disorders and other effects on the blood, caution is advised when they are given with drugs known to affect platelet function. SSRIs should not generally be given to patients receiving MAOIs or for at least 2 weeks after their use. At least one week should elapse between withdrawing an SSRI and starting any drug liable to provoke a serious reaction (e.g. phenelzine); in the case of the SSRI sertraline the drug-free interval is extended to 2 weeks, and for fluoxetine 5 weeks, because of their longer half-lives. Adverse effects such as the serotonin syndrome may also occur when the SSRIs are given with other drugs known to act on the same neurotransmitter, a consequence of synergistic interaction. ,
Ref :-   Book : Martindale    Page : 416,421,427   Edition : 37,


►  Contraindication : Because of their epileptogenic effect SSRIs should be used with caution in patients with epilepsy or a history of such disorders, SSRIs should also be used with caution in patients with cardiac disease or a history of bleeding disorders, Although SSRIs are preferred to tricyclics for the treatment of depression in patients with diabetes, they may alter glycaemic control and therefore caution is also warranted in diabetic subjects., SSRIs should be used with caution in patients with angle-closure glaucoma., It should be stopped in patients who develop a rash since systemic effects, possibly related to vasculitis, have occurred in such patients., SSRIs may impair performance of skilled tasks and, if affected, patients should not drive or operate machinery, hepatic impairment,
Ref :-   Book : Martindale    Page : 416,421,425   Edition : 37,
  ►  Mechanism of Action :   Prevention of the reuptake of monoamine transmitters such as serotonin, which potentiates their action in the brain, appears to be associated with antidepressant activity. SSRIs inhibit the reuptake of serotonin compared with noradrenaline and have limited direct action at other neurotransmitter sites, including muscarinic receptor,
Ref :-   Book : Martindale    Page : 416,422,428   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- BELLABONNA with Increasing anticholinergic activity of tricyclic antidepressants .,

  ►  Reference :-
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.

  •   ►  URL -- http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 416,422   Edition : 37,


    ►    Plasma Half-life :   Min value :-   27 hours,    Max value :-   32 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 529   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 416,422   Edition : 37,