Esmolol is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1412   Edition : 37,

  ►   Brandname : Miniblock

  ►  Strength : Injection with 10  mg/ml, Injection with 250  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 166   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1414   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Supraventricular arrhythmias IV infusion 500 micrograms/kg Injection Dose: Given over 1 minute is followed by an initial maintenance infusion of 50 micrograms/kg per minute for 4 minutes. If the response is satisfactory this maintenance infusion should be continued at 50 micrograms/kg per minute
2 hypertension IV infusion 80 mg Injection Dose: during anaesthesia: Given over 15 to 30 seconds followed by an infusion of 150 micrograms/kg per minute, increased as necessary up to 300 micrograms/kg per minute
3 Tachycardia IV infusion 80 mg Injection Dose: during anaesthesia: Given over 15 to 30 seconds followed by an infusion of 150 micrograms/kg per minute, increased as necessary up to 300 micrograms/kg per minute.
4 hypertension IV infusion 500 micrograms/kg/min Injection Dose: on waking from anaesthesia: Given for 4 minutes, followed by an infusion of 300 micrograms/kg per minute as required.
5 Tachycardia IV infusion 500 micrograms/kg/min Injection Dose: on waking from anaesthesia: Given for 4 minutes, followed by an infusion of 300 micrograms/kg per minute as required.
6 hypertension IV infusion 300 micrograms/kg/min Injection Postoperatively.
7 Tachycardia IV infusion 300 micrograms/kg/min Injection Postoperatively.

Ref :-  Book : Martindale    Page : 1412   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cardiac arrhythmias 1 month IV infusion 500 micrograms/kg Injection
2 Hypertensive emergencies 1 Month IV infusion 500 micrograms/kg Injection
3 Tetralogy of Fallot IV 600 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1412   Edition : 37,
►  Side Effect : heart failure, heart block, bronchospasm, fatigue, coldness of the extremities, bradycardia, hypotension, shortness of breath, dyspnoea, pneumonitis, pulmonary fibrosis, pleurisy, headache, Depression, Dizziness, hallucinations, Confusion, amnesia, Sleep disturbances, nightmares, coma, Convulsions, paraesthesia, arthralgia, myopathies, muscle cramps, Raynaud’s syndrome, nausea, vomiting, diarrhoea, constipation, abdominal cramp, Hypoglycaemia, Hyperglycaemia, changes in blood concentrations of triglycerides and cholesterol, Rashes, pruritus, exacerbation of psoriasis, excess sweating, reversible alopecia, Blurred Vision, conjunctivitis, soreness, nonthrombocytopenic purpura, thrombocytopenia, transient eosinophilia, Systemic lupus erythematous (SLE), dry mouth, raised liver enzymes, male impotence, sclerosing peritonitis, retroperitoneal fibrosis, abrupt withdrawal of beta blocker may exacerbate angina and sudden death, Local irritation at the site of infusion, inflammation, induration, and thrombophlebitis have occurred and necrosis is a hazard of extravasation, ,
Ref :-   Book : Martindale    Page : 1349,1411   Edition : 37,

►  Drug Interaction : Drug interaction of Esmolol is with Angiotensin conveting enzyme inhibitors , Calcium Channel Blockers , General anaesthetics , NSAIDS, Antiarrhythmics, Sympathomimetic Drugs , Oral Hypoglycemic Drugs, , Barbiturates ,  Clonidine , Aldesleukin , Verapamil , Epinephrine (adrenaline) , Insulin , Cholestyramine , Rifampicin , Cimetidine , Erythromycin , Fluvoxamine, Hydralazine , Labetalol , Propranolol , Timolol , Atenolol , Nadolol,
Ref :-   Book : Martindale    Page : 1352,1411   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that enhance the antihypertensive effects of beta blockers, such as ACE inhibitors, calcium-channel blockers, and clonidine may be useful in controlling hypertension. Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calciumchannel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Patients taking beta blockers may have an exaggerated hypertensive response to adrenaline, caused by unopposed alpha-mediated vasoconstriction, while the bronchodilator effects are inhibited; the response to adrenaline given for anaphylaxis may also be reduced in patients on long-term treatment with beta blockers. In diabetic patients beta blockers can reduce the response to insulin and oral hypoglycaemics through their effects on pancreatic beta receptors. Drugs that reduce absorption include aluminium salts and bile-acid binding resins such as colestyramine. Metabolism of some beta blockers can be increased by drugs such as barbiturates and rifampicin and decreased with drugs such as cimetidine, erythromycin, fluvoxamine, and hydralazine. Drugs that alter hepatic blood flow also affect metabolism of some beta blockers. For example, cimetidine and hydralazine decrease hepatic blood flow and this contributes to the decreased hepatic clearance seen with these drugs. Drugs that influence hepatic metabolism affect beta blockers that are extensively metabolised, such as labetalol, propranolol, and timolol, while beta blockers that are excreted largely unchanged, for example atenolol and nadolol, are unaffected.,
Ref :-   Book : Martindale    Page : 1352,1411   Edition : 37,


►  Contraindication : Bronchospasm, asthma, metabolic acidosis, cardiogenic shock, hypotension, severe peripheral arterial disease, Sinus bradycardia, second -or- third degree AV block, uncontrolled heart failure, hyperthyroidism, hypoglycemia, prinzmetal angina, severity of anaphylactoid reactions, Pregnancy, Phaeochromocytoma should not be given beta blockers without alpha-adrenoceptor blocking therapy as well,
Ref :-   Book : Martindale    Page : 1351,1411   Edition : 37,
  ►  Mechanism of Action :   Esmolol is a cardioselective short-acting beta blocker It is reported to be lacking in intrinsic sympathomimetic and membrane-stabilising properties.,
Ref :-   Book : Martindale    Page : 1412   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Buckwheat with Another pathway,

  ►  Pathway with its reference as follows :-
  • High Magnecium have antihypertensive activity --- ( Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart. )

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1411   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA