Esomeprazole is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1881   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Esomac,Sompraz,Nexium,Esofag,Esofine-DSR,Esokem,Esokem D,Sompraz D,Sompraz D 40

  ►  Strength : Delayed-release capules with 20  mg, Delayed-release capules with 40  mg, Injection with 20  mg, Injection with 40  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1909   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Peptic ulcer disease Oral 20 mg Capsule b.d. Dose: Given as as a component of a triple therapy regimen with amoxicillin and clarithromycin, daily for 7 days.
2 Peptic ulcer disease Oral 40 mg Capsule o.d. Dose: Given as as a component of a triple therapy regimen with amoxicillin and clarithromycin, daily for 10 days.
3 NSAIDS associated ulcer Oral 20 mg Capsule Dose: Given daily, for 4 to 8 weeks.
4 Gastro-oesophageal reflux disease Oral 40 mg Capsule o.d. Dose: Given for 4 weeks, extended for a further 4 weeks if necessary.
5 Zollinger-ellison syndrome Oral 40 mg Capsule b.d.
6 Prevention of rebleeding IV infusion 80 mg Injection Dose: For gastric and duodenal ulcers after therapeutic endoscopy: Given over 30 minutes, followed by a continuous intravenous infusion of 8 mg/hour over 72 hours. Then parenteral treatment period is then followed by oral therapy; 40 mg is given once daily for 4 weeks.

Ref :-  Book : Martindale    Page : 1881   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gastro-oesophageal reflux disease 1 Year 11 Year 10 mg o.d.
2 Gastro-oesophageal reflux disease 12 Year 17 Year 20 40 mg o.d.
3 Erosive esophagitis less than 20 kg 10 mg o.d.
4 Erosive esophagitis 20 kg or over 10 mg o.d.

Ref :- Book : Martindale    Page : 1881   Edition : 37,
►  Side Effect : headache, diarrhea, Skin rashes, pruritus, Dizziness, fatigue, constipation, nausea, vomiting, Flatulence, abdominal pain, arthralgia, myalgia, Urticaria, dry mouth, photosensitivity, bullous eruptions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, hypersensitivity reactions, bronchospasm, angioedema, anaphylaxis, gastrointestinal tumours, fever, insomnia, Somnolence, vertigo, agitation, Depression, hallucinations, raised liver enzymes, hepatitis, jaundice, hepatic failure, Reversible confusional states, Hepatic encephalopathy, ,
Ref :-   Book : Martindale    Page : 1880,1906   Edition : 37,

►  Drug Interaction : Drug interaction of Esomeprazole is with Warfarin , Diazepam , Ketoconazole , Phenytoin , Voriconazole , Itraconazole , Atazanavir, Dasatinib,
Ref :-   Book : Martindale    Page : 1880,1908-1909   Edition : 37, Martindale    Page : 1880,1908-1909   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Proton pump inhibitors are metabolised by the cytochrome P450 system, primarily by isoenzyme CYP2C19, and to a smaller extent by CYP3A4. Inhibitors or inducers of these isoenzymes may affect exposure to omeprazole and other proton pump inhibitors. In turn, proton pump inhibitors may alter the metabolism of some drugs metabolised by these enzymes. Esomeprazole may prolong the elimination of diazepam, phenytoin, and warfarin. esomeprazole and other proton pump inhibitors can reduce the absorption of drugs such as dasatinib, ketoconazole, and itraconazole, whose absorption is dependent on an acid gastric pH. With voriconazole, the plasma concentration of both drugs may be increased. Other proton pump inhibitors may be similarly affected by voriconazole. Esomeprazole and other proton pump inhibitors should not be used with atazanavir, as it substantially reduces exposure to atazanavir. ,
Ref :-   Book : Martindale    Page : 1880,1908-1909   Edition : 37,


►  Contraindication : Hypersensitivity, Proton pump inhibitors should be used with caution in hepatic impairment and dose adjustment may be required,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3, Martindale    Page : 1880,1908   Edition : 37,
  ►  Mechanism of Action :   The activated form of esomeprazole binds covalently with sulfhydryl groups of cysteines in the H+, K+ ATPase, irreversibly inactivating the pump molecule. ,
Ref :-   Book : Goodman    Page : 1311   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Quercetin with same pathway,

  ►  Pathway with its reference as follows :-
  • Proton-Pump inhibitor --- (Chatterjee A, Bandyopadhyay S. Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing. Ulcers. 2014;2014:1-13. )

  •   ►  URL -- file:///C:/Users/DR%20lounge/Downloads/361586.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Fecal,
    Ref :-   Book : Martindale    Page : 1880   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1.3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1880   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1880   Edition : 37,