Estradiol cypionate is a Medicine belongs to Estrogen group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,

  ►   Brandname : Depo-estradiol

  ►  Strength : Injection with 5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM,
Reference :-   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 IM 2 5 mg Injection Dose: Given every 3-4 weeks.

Ref :-  Book : Basic & Clinical pharmacology    Page : 719   Edition : 12,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, abdominal cramp, bloating, weight changes, breast enlargement, tenderness, cholestatic jaundice, glucose intolerance, Rashes, Chloasma, changes in libido, migraine, Dizziness, Depression, mood changes, headache, leg cramps, vaginal candidiasis, Premenstrual like syndrome, Sodium and fluid retention, Altered blood lipids, Decreased tolerance of contact lense,
Ref :-   Book : Martindale    Page : 2303,2275   Edition : , Martindale    Page : 2303,2275   Edition : 37,

►  Drug Interaction : Drug interaction of Estradiol cypionate is with Oral Contraceptive, , , Alcohol, ,  Griseofulvin , Rifampicin , Modafinil , Phenytoin , Levothyroxine,
Ref :-   Book : Martindale    Page : 2271,2280,2304   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that increase the hepatic metabolism of oestrogens and progestogens have been associated with failure of the combined oral contraceptive. Enzyme-inducing drugs can cause combined oral contraceptives to fail by increasing their metabolism and clearance. This effect is well established for a number of antiepileptics, griseofulvin, and rifamycin antibacterials, and has also been suggested for some antivirals and for modafinil. Although less well documented, these interactions would also be expected to apply to progestogen-only contraceptives. Although oral contraceptives alter the effects of a number of drugs, the lower doses of oestrogens used in HRT are considered less likely to induce interactions, although the possibility remains. Both alcohol consumption and HRT are risk factors for breast cancer. Phenytoin was reported to reduce the effect of conjugated oestrogens in a menopausal woman. Increased doses of levothyroxine may be needed in hypothyroid women who receive oestrogens for postmenopausal HRT. Antoxidant effect of ascorbic acid might reverse the oxidation of oestrogens. ,
Ref :-   Book : Martindale    Page : 2271,2280,2304   Edition : 37,


►  Contraindication : Oestrogen- dependent neoplasms, active liver disease, Rotor syndromes, Women with untreated endometrial hyperplasia, HRT should be avoided in women with active thrombophlebitis or thromboembolic disease; it should not be given to those with a history of recurrent thromboembolism unless they are already receiving anticoagulant treatment, HRT should not be given to those with undiagnosed abnormal vaginal bleeding, and abnormal vaginal bleeding during therapy should be investigated, HRT should be used with caution in women with antiphospholipid antibodies or predisposing factors to thromboembolism and in migraine, a history of breast nodules or fibrocystic disease, uterine fibroids, or a history of endometriosis, HRT should also be used with caution in women with diabetes because of the increased risk of heart disease, Consideration should be given to temporarily stopping HRT 4 to 6 weeks before elective surgery, Oestrogens should be used with caution in children because premature closure of the epiphyses may occur resulting in inhibited linear growth and small stature, Oestrogens have been reported to interfere with some diagnostic tests such as those for thyroid function and glucose tolerance,
Ref :-   Book : Martindale    Page : 2279,2303   Edition : 37,
  ►  Mechanism of Action :   Estradiol is the most active of the naturally occurring oestrogens. Plasma estrogens in the blood and interstitial fluid are bound to SHBG, from which they dissociate to enter the cell and bind to their receptor. Two genes code for two estrogen receptor isoforms, α and β, which are members of the superfamily of steroid, sterol, retinoic acid, and thyroid receptors. Binding of the hormone to its receptor alters its conformation and releases it from the stabilizing proteins (predominantly Hsp90). The receptor-hormone complex forms homodimers that bind to a specific sequence of nucleotides called estrogen response elements (EREs) in the promoters of various genes and regulate their transcription. Ref: Martindale pg no 2304 ed 37,
Ref :-   Book : Basic & Clinical pharmacology    Page : 718-719   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red clove with same pathway,

  ►  Pathway with its reference as follows :-
  • Red clove is helpful in the production of estrogen --- (Ehsanpour S, Salchi K. The effects of red clover on quality of life in post-menopausal women. Iran J Nurs Midwifery Res. 2012;17(1):34-40. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590693/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- SENNA LEAVES with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GRAPE FRUIT JUICE with It increases estradiol levels in the blood ., VITAMIN D with Increase synthesis of 1,25 oh2vitamin d., CALCIUM with increase calcium absorption & decreases urinary cxcretion .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal, Fecal,
    Ref :-   Book : Martindale    Page : 2303   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA