Estramustine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 786   Edition : 37,

  ►   Brandname : X-Trant,Emcyt,Estracyt

  ►  Strength : Capsule with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 786   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 786   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Advanced prostatic carcinoma Oral 14 mg/kg Capsule Dose: daily in divided doses is used. The usual initial dose is 560 to 840 mg daily, which may be adjusted to between 140 mg and 1.4 g daily according to the response and gastrointestinal tolerance. It should be given not less than 1 hour before or 2 hours after meals.

Ref :-  Book : Martindale    Page : 786   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Gynaecomastia, fluid retention, gastrointestinal disturbance, hepatic dysfunction, loss of libido, hypersensitivity reactions, leucopenia, thrombocytopenia, Cardiovascular effects,
Ref :-   Book : Martindale    Page : 786   Edition : 37,

►  Drug Interaction : Drug interaction of Estramustine is with , , Angiotensin converting enzyme inhibitor,  NA

  ►    Mechanism of Drug Drug Interaction :  Estramustine sodium phosphate should not be given with milk products or products high in calcium, which may interfere with its absorption. Hypersensitivity reactions including angioedema have occurred rarely in patients given estramustine who were also receiving an ACE inhibitor,
Ref :-   Book : Martindale    Page : 786   Edition : 37,


►  Contraindication : active thrombophlebitis, Thromboembolic disorder, Peptic ulceration, cardiovascular disease, Severe hepatic disease,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3, Martindale    Page : 786   Edition : 37,
  ►  Mechanism of Action :   Covalently bind DNA, often cross-link to DNA or associated proteins,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red clove with same pathway,

  ►  Pathway with its reference as follows :-
  • Red clove is helpful in the production of estrogen --- (Ehsanpour S, Salchi K. The effects of red clover on quality of life in post-menopausal women. Iran J Nurs Midwifery Res. 2012;17(1):34-40. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590693/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal,
    Ref :-   Book : Goodman    Page : 1709   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   10 hours,
    Ref :-   Book : Goodman    Page : 1709   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA