Etanercept is a Medicine belongs to Antirheumatic group whose information about Brand can be referenced from   Book : Martindale    Page : 54   Edition : 37,

  ►   Brandname : Enbrel

  ►  Strength : Injection with 50  mg/ml, Injection with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC,
Reference :-   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Psoriasis SC 25 mg Injection Dose: Given twice weekly. Alternatively, an initial dose of 50 mg twice weekly at intervals of 3 or 4 days may be given for 12 weeks; the dose should then be reduced to 25 mg twice weekly or 50 mg weekly
2 Rheumatoid arthiritis SC 25 mg Injection Dose: Given twice weekly at intervals of 3 or 4 days.
3 Psoriatic arthiritis SC 25 mg Injection Dose: Given twice weekly at intervals of 3 or 4 days.

Ref :-  Book : Martindale    Page : 53   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Juvenile idiopathic arthritis 4 Year SC 400 micrograms/kg Injection
2 Juvenile idiopathic arthritis 2Year SC 800 micrograms/kg Injection
3 Plaque psoriasis 8 Year SC 800 micrograms/kg Injection QWK

Ref :- Book : Martindale    Page : 53   Edition : 37,
►  Side Effect : injection-site reactions, headache, Dizziness, asthenia, dyspepsia, allergic reactions, fever, chill, pruritus, Urticaria, chest pain, hypertension, hypotension, nausea, vomiting, abdominal pain, diarrhoea, fatigue, back pain, opportunistic infections, sepsis, pneumonia, onset or reactivation of tuberculosis, particularly in patients with underlying conditions predisposing them to infections; in some cases death has resulted, ,
Ref :-   Book : Martindale    Page : 52,72   Edition : 37,

►  Drug Interaction : Drug interaction of Etanercept is with Live Vaccines,  Sulfasalazine,
Ref :-   Book : Martindale    Page : 52,74   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Live vaccines should not be given with etanercept or other drugs that inhibit TNF as the effect of such drugs on vaccine efficacy or the risk of infection transmission is unknown. The use of TNF inhibitors with the interleukin- 1 receptor antagonist anakinra may increase the risk of serious infections and neutropenia; such combinations are not recommended. The use of etanercept with sulfasalazine has resulted in decreased white blood cell counts; however, the clinical significance of this is unknown. For an increased incidence of malignancy when etanercept was added to standard immunosuppressive therapy in patients with Wegener’s granulomatosis.,
Ref :-   Book : Martindale    Page : 52,74   Edition : 37,


►  Contraindication : heart failure, TNF inhibitors should not be given to patients with severe infection, including active tuberculosis, abscesses, and opportunistic infections, and should be stopped if these develop,
Ref :-   Book : Martindale    Page : 52,72   Edition : 37,
  ►  Mechanism of Action :   Etanercept is a recombinant fusion protein consisting of two soluble TNF p75 receptor moieties linked to the F c portion of human IgG 1; it binds TNF-α molecules and also inhibits lymphotoxin-α.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 648   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Bayleaf with Another pathway,

  ►  Pathway with its reference as follows :-
  • antirheumatic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- POTASSIUM with It may increase the risk of hyperkalaemia possibly leading to serious side effects .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   48 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 53   Edition : 37,