Ethambutol is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 299   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Combutol,Mycobact,Myambutol,EMB,Akurit 4,AKT-3

  ►  Strength : Tablet with 100  mg, Tablet with 400  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis Oral 15 mg/kg Tablet Dose: Given single daily dose, ethambutol is given, as the hydrochloride, usually with isoniazid, rifampicin, and pyrazinamide in the initial 8-week phase and sometimes in the continuation phase.
2 Tuberculosis Oral 30 mg/kg Tablet Dose: given three times weekly, as the hydrochloride, usually with isoniazid, rifampicin, and pyrazinamide in the initial 8-week phase and sometimes in the continuation phase.
3 Tuberculosis Oral 25 mg/kg Tablet Dose: Patients who have previously had antimycobacterial therapy daily for 60 days reduced to 15 mg/kg daily thereafter. Ethambutol is given, as the hydrochloride, usually with isoniazid, rifampicin, and pyrazinamide in the initial 8-week phase and sometimes in the continuation phase.

Ref :-  Book : Martindale    Page : 299   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis Oral 20 25 mg/kg Tablet
2 Congenitally acquired tuberculosis Oral 15 mg/kg Tablet o.d.

Ref :- Book : Martindale    Page : 299   Edition : 37,
Precaution :- If a Patient is using 'Ethambutol' drug in TUBERCULAR MENINGITIS disease, then Please not be given   if he ever suffered from papilloedema disease.
Precaution :- If a Patient is using 'Ethambutol' drug in  TUBERCULOSIS  disease, then Please Contraindications: Optic neuritis Hypersensitivity .

Precaution :- If a Patient is using 'Ethambutol' drug in  TUBERCULOSIS  disease, then Please Lactation: enters breast milk; use with caution .

►  Side Effect : retrobulbar neuritis with a reduction in visual acuity, constriction of visual field, central or peripheral scotoma, green-red colour blindness, Confusion, disorientation, hallucinations, headache, Dizziness, malaise, jaundice, Transient liver dysfunction, peripheral neuropathy, thrombocytopenia, Pulmonary infiltrates, eosinophilia, Gastrointestinal disturbances, nausea, vomiting, anorexia, abdominal pain, ,
Ref :-   Book : Martindale    Page : 298   Edition : 37,

►  Drug Interaction : Drug interaction of Ethambutol is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Optic neuritis, renal impairment,
Ref :-   Book : Martindale    Page : 298   Edition : 37,
  ►  Mechanism of Action :   Ethambutol inhibits arabinosyl transferase III, thereby disrupting the transfer of arabinose into arabinogalactan biosynthesis, which in turn disrupts the assembly of mycobacterial cell wall. The arabinosyl transferases are encoded by embAB genes,
Ref :-   Book : Goodman    Page : 1558   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Chaulmoogra with Another pathway, Chaulmoogra with Another pathway,

  ►  Pathway with its reference as follows :-
  • chauylmogranic acid have antitubercular effect --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Anti tubercular effect --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
    Ref :-   Book : Martindale    Page : 299   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   3 hours ,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 299   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA