Ethinylestradiol is a Medicine belongs to Estrogen group whose information about Brand can be referenced from   Book : Martindale    Page : 2308   Edition : 37,

  ►   Brandname : Lynoral,Estinyl

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2308   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2308   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral contraceptives Oral 20 40 micrograms Tablet Dose: Given daily.
2 Menopausal HRT Oral 10 50 micrograms Tablet Dose: have been given cyclically (with a progestogen in women with a uterus), but preparations providing lower doses of 2.5 or 5 micrograms daily are also available.
3 Female hypogonadism Oral 10 50 micrograms Tablet Dose: Given daily on a cyclical basis have been used.
4 Prostate cancer Oral 150 micrograms 1.5 mg Tablet Dose: Given daily.

Ref :-  Book : Martindale    Page : 2308   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Delayed puberty in girls Oral 2 micrograms Tablet
2 Tall stature 2 Year 12 Year Oral 20 50 micrograms Tablet

Ref :- Book : Martindale    Page : 2308   Edition : 37,
►  Side Effect : nausea, vomiting, abdominal cramp, bloating, weight changes, weight changes, breast enlargement, tenderness, cholestatic jaundice, glucose intolerance, Rashes, Chloasma, changes in libido, migraine, Dizziness, Depression, mood changes, headache, leg cramps, vaginal candidiasis, Premenstrual like syndrome, Sodium and fluid retention, Altered blood lipids, Decreased tolerance of contact lense, spotting, Breakthrough bleeding, amenorrhoea,
Ref :-   Book : Martindale    Page : 2303,2308,2263,2275   Edition : 37,

►  Drug Interaction : Drug interaction of Ethinylestradiol is with Oral Contraceptive, Alcohol, , , ,  Griseofulvin , Rifampicin , Modafinil , Phenytoin , Levothyroxine,
Ref :-   Book : Martindale    Page : 2271,2280,2308   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that increase the hepatic metabolism of oestrogens and progestogens have been associated with failure of the combined oral contraceptive. Enzyme-inducing drugs can cause combined oral contraceptives to fail by increasing their metabolism and clearance. This effect is well established for a number of antiepileptics, griseofulvin, and rifamycin antibacterials, and has also been suggested for some antivirals and for modafinil. Although less well documented, these interactions would also be expected to apply to progestogen-only contraceptives. Although oral contraceptives alter the effects of a number of drugs, the lower doses of oestrogens used in HRT are considered less likely to induce interactions, although the possibility remains. Both alcohol consumption and HRT are risk factors for breast cancer. Phenytoin was reported to reduce the effect of conjugated oestrogens in a menopausal woman. Increased doses of levothyroxine may be needed in hypothyroid women who receive oestrogens for postmenopausal HRT. Antoxidant effect of ascorbic acid might reverse the oxidation of oestrogens. ,
Ref :-   Book : Martindale    Page : 2271,2280,2308   Edition : 37,


►  Contraindication : Oestrogen- dependent neoplasms, active liver disease, Rotor syndromes, Women with untreated endometrial hyperplasia, HRT should be avoided in women with active thrombophlebitis or thromboembolic disease; it should not be given to those with a history of recurrent thromboembolism unless they are already receiving anticoagulant treatment, HRT should not be given to those with undiagnosed abnormal vaginal bleeding, and abnormal vaginal bleeding during therapy should be investigated, HRT should be used with caution in women with antiphospholipid antibodies or predisposing factors to thromboembolism and in migraine, a history of breast nodules or fibrocystic disease, uterine fibroids, or a history of endometriosis, HRT should also be used with caution in women with diabetes because of the increased risk of heart disease, Consideration should be given to temporarily stopping HRT 4 to 6 weeks before elective surgery, Oestrogens should be used with caution in children because premature closure of the epiphyses may occur resulting in inhibited linear growth and small stature, Oestrogens have been reported to interfere with some diagnostic tests such as those for thyroid function and glucose tolerance,
Ref :-   Book : Martindale    Page : 2303,2308,2279   Edition : 37,
  ►  Mechanism of Action :   Supress GnRH, LH, and FSH secretion and follicular development, thereby inhibiting ovulation; secondary mechanism of pregnancy prevention include alteration in tubal peristalsis, endometrial receptivity, and cervical mucus secretions, which together prevent the proper transport of both egg and sperm,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 523   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red clove with same pathway,

  ►  Pathway with its reference as follows :-
  • Red clove is helpful in the production of estrogen --- (Ehsanpour S, Salchi K. The effects of red clover on quality of life in post-menopausal women. Iran J Nurs Midwifery Res. 2012;17(1):34-40. )

  •   ►  URL -- 2012;17(1):34-40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590693/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Fecal,
    Ref :-   Book : Martindale    Page : 2308   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   13 hours,    Max value :-   27 hours,
    Ref :-   Book : Goodman    Page : 1174   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,