Ethosuximide is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 523   Edition : 37,

  ►   Brandname : Zarontin; Petnidan; Suxilep

  ►  Strength : Capsule with 250  mg, Syrup with 250/5  mg/ml, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12, Martindale    Page : 523   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 523   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antiepileptic Oral 500 mg Dose: Given daily. The dosage is then adjusted in steps of 250 mg every 4 to 7 days, according to response.

Ref :-  Book : Martindale    Page : 523   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antiepileptic 6 Year Oral 250 mg

Ref :- Book : Martindale    Page : 523   Edition : 37,
►  Side Effect : nausea, vomiting, diarrhoea, anorexia, Gastric upset, abdominal pain, headache, fatigue, lethargy, drowsiness, Dizziness, ataxia, hiccup, Mild euphoria, eosinophilia, leucopenia, agranulocytosis, thrombocytopenia, pancytopenia, aplastic anaemia, fatalities, Abnormal renal and liver function values, ,
Ref :-   Book : Martindale    Page : 522   Edition : 37,

►  Drug Interaction : Drug interaction of Ethosuximide is with Antiepileptics ,  NA

  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy,
Ref :-   Book : Martindale    Page : 523   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 522   Edition : 37,
  ►  Mechanism of Action :   It has an important effect on calcium currents, reducing the low threshold T type current. The T type Ca currents provide a pacemaker current in Thalamic Neurons responsible for generating the rhythmic cortical discharge of an absence attack.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 417   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Valerian with Another pathway,

  ►  Pathway with its reference as follows :-
  • Valeremic acid have Anticonvulsant --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN E with Impairs vitamin metabolism. ,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 523   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   7 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 417   Edition : 12,