Etodolac is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 55   Edition : 37,

  ►   Brandname : Eccoxolac,Etopan,Lodine

  ►  Strength : Capsule with 200  mg, Capsule with 300  mg, Tablet with 400  mg, Tablet with 500  mg, Tablet (Extended Release Tablets) with 400  mg, Tablet (Extended Release Tablets) with 500  mg, Tablet (Extended Release Tablets) with 600  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 55   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Rheumatoid arthiritis Oral 0.6 1 gm Dose: Given daily in divided doses adjusted according to response; single daily doses of up to 600 mg may also be given.
2 Osteoarthritis Oral 0.6 1 gm Dose: Given daily in divided doses adjusted according to response; single daily doses of up to 600 mg may also be given.
3 acute pain Oral 200 400 mg Dose: Given every 6 to 8 hours to a maximum of 1 g daily

Ref :-  Book : Martindale    Page : 55   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Juvenile idiopathic arthritis 6 Year 16 Year 20 to 30 kg Oral 400 mg o.d.
2 Juvenile idiopathic arthritis 6 Year 16 Year 31 to 45 kg Oral 600 mg o.d.
3 Juvenile idiopathic arthritis 6 Year 16 Year 46 to 60 kg Oral 800 mg o.d.
4 Juvenile idiopathic arthritis 6 Year 16 Year over 60 kg Oral 1 gm o.d.

Ref :- Book : Martindale    Page : 55   Edition : 37,
►  Side Effect : gastrointestinal disturbance, nausea, diarrhoea, headache, vertigo, Dizziness, Nervousness, tinnitus, anaemia, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, Depression, drowsiness, insomnia, hypersensitivity reactions, fever, angioedema, bronchospasm, Rashes, visual disturbances, photosensitivity, Induction or exacerbation of colitis, fluid retention, ,
Ref :-   Book : Martindale    Page : 54,100   Edition : 37,

►  Drug Interaction : Drug interaction of Etodolac is with , Cardiac Glycosides, Angiotensin converting enzyme inhibitor, , Diuretic Agents , Potassium -Sparing Diuretics , Beta Blockers , sulfonylurea antidiabetic , Corticosteroid , selective serotonin reuptake inhibitors, Selective nonadrenaline reuptake inhibitors, Alcohol, ,  Azapropazone, Phenylbutazone, Methotrexate, Tacrolimus , Phenytoin , Venlafaxine , Clopidogrel , Ticlopidine , Iloprost , Erlotinib, Sibutramine, Pentoxifylline , Ritonavir, Mifepristone ,
Ref :-   Book : Martindale    Page : 54,103   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. Ritonavir may increase the plasma concentrations of NSAIDs. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by NSAIDs or aspirin may alter the efficacy of mifepristone.,
Ref :-   Book : Martindale    Page : 54,103   Edition : 37,


►  Contraindication : Active peptic ulceration, severe heart failure, Moderate to severe heart failure, ischaemic heart disease, peripheral arterial disease, Cerebrovascular disease, hypertension, Left ventricular failure, Oedema, history of hypersensitivity reactions, History of cardiac failure, and in patients with risk factors for developing heart disease, It should also be used with caution in patients with asthma or allergic disorders,
Ref :-   Book : Martindale    Page : 54,102   Edition : 37,
  ►  Mechanism of Action :   Inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with same pathway,

  ►  Pathway with its reference as follows :-
  • Ginger having active constituent gingerol which act as COX-2 inhibitor . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- COPPER with Dietary Substance is Drug Enhancer, IRON with Decrease in Nutrient Level, LITHIUM with Increase in Nutrient Level, POTASSIUM with Increase in Nutrient Level, SODIUM with Increase in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- LITHIUM with Most NASDs inhibit the exretion of lithium from the body , resulting in higher blood levels of the mineral , though sulindac .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 54   Edition : 37,


    ►    Plasma Half-life :   Min value :-   7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 54   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 54   Edition : 37,