Etomidate is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1940   Edition : 37  

  ►   Brandname : Amidate, Hypnomidate
  ►  Strength : Injection with 2 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, rectal
Reference :-   Book : Goodman    Page : 1940   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Sedation IV infusion 5 micrograms/kg/min Injection
2 Induction of anaesthesia rectal 6.5 mg/kg Dose: Given in patients at risk for hypotension.
3 Induction of anaesthesia IV infusion 0.2 0.6 mg/kg Injection Dose: Given in patients at risk for hypotension.
4 Induction of anaesthesia Injection etomidate is available as a conventional or an emulsion injection formulation. The usual dose is 300 micrograms/kg of etomidate given slowly, preferably into a large vein in the arm, although a lower dose of 150 micrograms/kg of the emulsion formulation may be sufficient. An initial dose of 150 to 200 micrograms/kg is recommended in the elderly, subsequently adjusted according to effects.

Ref :-  Book : Goodman    Page : 538   Edition : 12   Martindale    Page : 1940   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Induction of anaesthesia

Ref :- Book : Martindale    Page : 1940   Edition : 37  
►  Side Effect : Pain at the injection site, Hypersensitivity reactions, Anaphylaxis, Involuntary muscle movements, Hiccup, Coughing, Bronchospasm, Laryngospasm, Respiratory depression, Hypotension, Mild hypothermia, Drowsiness, Postoperative nausea with or without vomiting, Anorexia, Malaise, Fatigue, Dizziness, Headache, Dry mouth, Jaw pain, Muscle pain, Malignant hyperthermia
Ref :-   Book : Martindale    Page : 1935,1939   Edition : 37.  

►  Drug Interaction : Drug interaction of Etomidate is with Angiotensin converting enzyme inhibitor, Tricyclic antidepressants, Monoamine Oxidase Inhibitor, Antihypertensive Agents , Antipsychotics, Beta Blockers , Sedatives, Opioids,  Epinephrine (adrenaline) , Isoprenaline (Isoproterenol)
Ref :-   Book : Martindale    Page : 1935,1940   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Sensitisation of the myocardium to beta-adrenergic stimulation occurs with some anaesthetics and ventricular fibrillation may occur if sympathomimetics such as adrenaline and isoprenaline are also used. Enhanced hypotensive effects may result when anaesthetics are given with ACE inhibitors, tricyclic antidepressants (which may also increase the risk of arrhythmias), MAOIs, antihypertensives, antipsychotics, or beta blockers A reduced dose of etomidate may be necessary in patients who have received antipsychotics, sedatives, or opioids. The hypnotic effect of etomidate has been potentiated by other sedative drugs.
Ref :-   Book : Martindale    Page : 1935,1940   Edition : 37.  

►  Contraindication : Epilepsy
Ref :-   Book : Martindale    Page : 1939   Edition : 37.  
  ►  Mechanism of Action :   A variety of ligand-gated ion channels, receptors and signal transduction proteins are modulated by general anesthetics.Chloride channels gated by the inhibitory GABA A receptors are sensitive to clinical concentrations of a wide variety of anesthetics, including etomidate. The capacity of propofol and etomidate to inhibit the response to noxious stimuli is mediated by a specific site on the β subunit of the GABA A receptor, whereas the sedative effects of these anesthetics are mediated by the same site on the β subunit.These results indicate that two components of anesthesia can be mediated by GABA A receptors
Ref :-   Book : Goodman    Page : 531   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Renal
Ref :-   Book : Martindale    Page : 1940   Edition : 37.  

►    Plasma Half-life :   Min value :-   2.9 hours,    Max value :-   5.3 hours.  
Ref :-   Book : Basic & Clinical pharmacology    Page : 439   Edition : 12.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .