Etoposide is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 788   Edition : 37  

  ►   Brandname : Vepesid, Bioposide, Etosid, Eto-cell, ETO CS
  ►  Strength : Injection with .  Capsule with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 788   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV
Reference :-   Book : Martindale    Page : 786   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antineoplastic IV 50 120 mg/m2 Injection Dose: Given daily for 5 days.
2 Antineoplastic Oral 100 240 mg/m2 Capsule Dose: Given daily for 5 consecutive days.

Ref :-  Book : Martindale    Page : 788   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Nausea, Vomiting, Anorexia, Diarrhoea, Mucositis, Gastrointestinal toxicity, Reversible alopecia, Hypersensitivity reactions, Anaphylactoid reactions, Flushing, Chills, Fever, Tachycardia, Bronchospasm, Dyspnoea, Hypotension, Apnoea, Fatal reactions associated with bronchospasm, Peripheral neuropathies, Peripheral neuropathy, Central neuropathy, Weakness, Fatigue, Somnolence, Aftertaste, Rashes, Urticaria, Skin pigmentation, pruritus, Dysphagia, Cardiotoxicity, Local irritation at the injection site, Thrombophlebitis at the site of injection
Ref :-   Book : Martindale    Page : 787   Edition : 37.  

►  Drug Interaction : Drug interaction of Etoposide is with , Live Vaccines,  Phenylbutazone, Salicylic acid , Levamisole
Ref :-   Book : Martindale    Page : 698,786   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Phenylbutazone, salicylic acid, and sodium salicylate can affect the protein binding of etoposide. Caution is advised when etoposide phosphate is given with drugs such as levamisole hydrochloride that are known to inhibit phosphatase activities. Because of their effects on the gastrointestinal mucosa antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalized infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted.
Ref :-   Book : Martindale    Page : 698,786   Edition : 37.  

►  Contraindication : Severe hepatic impairment, Pregnancy, Breast feeding, Great caution is needed when the marrow is already depressed from radiotherapy or therapy with other antineoplastics, and modification of dosage regimens may be required
Ref :-   Book : Martindale    Page : 697,786   Edition : 37.  
  ►  Mechanism of Action :   Etoposide is a semisynthetic derivative of podophyllotoxin with antineoplastic properties; it interferes with the function of topoisomerase II thus inhibiting DNA synthesis, and is most active against cells in late S and G2 phases of cell cycle
Ref :-   Book : Martindale    Page : 786   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Mayapple i e ban kakri with Another pathway.   Holy basil with Another pathway.  

  ►  Pathway with its reference as follows :-
  • etoposite have anticancer effect --- ( Umadevi, M. (2013). Traditionally used anticancer herb in India. Journal Of Medicinal Plant Study, 1(3). )
  • Anticancer effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal
    Ref :-   Book : Martindale    Page : 787   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA