Etoricoxib is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 56   Edition : 37,

  ►   Brandname : Ebov,Ecoxib,Etozox,Arcoxia

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 56   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 56   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Osteoarthritis Oral 30 mg Tablet o.d. Dose: increased to 60 mg once daily if necessary.
2 Rheumatoid arthritis Oral 90 mg Tablet o.d. Dose changes is required in patients with hepatic impairment.
3 Ankylosing spondylitis Oral 90 mg Tablet o.d. Dose changes is required in patients with hepatic impairment.
4 Gouty arthritis Oral 120 mg Tablet o.d. Although such doses should only be used for the acute symptomatic period and for a maximum of 8 days.

Ref :-  Book : Martindale    Page : 56   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypersensitivity reactions, anaphylaxis, angioedema, Gastrointestinal disturbances, nausea, vomiting, diarrhoea, vertigo, Dizziness, Nervousness, tinnitus, Depression, drowsiness, insomnia, visual disturbances, anaemias, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, fluid retention, photosensitivity, Alveolitis, pulmonary eosinophilia, Pancreatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, Induction or exacerbation of colitis, ,
Ref :-   Book : Martindale    Page : 55,100   Edition : 37,

►  Drug Interaction : Drug interaction of Etoricoxib is with Salbutamol , Minoxidil , Ethinylestradiol ,
Ref :-   Book : Martindale    Page : 55-56   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The metabolism of etoricoxib is mediated by the cytochrome P450 isoenzyme CYP3A4. Use with other drugs that inhibit or induce this isoenzyme may result in changes in plasma concentration of etoricoxib. The metabolism of etoricoxib is mediated by the cytochrome P450 isoenzyme CYP3A4. Use with other drugs that inhibit or induce this isoenzyme may result in changes in plasma concentration of etoricoxib. Etoricoxib is an inhibitor of human sulfotransferase activity and has been shown to increase the plasma concentration of ethinylestradiol. Interactions with other drugs, such as oral salbutamol and minoxidil, also metabolised by this enzyme may be a possibility and licensed product information advises care with such combinations,
Ref :-   Book : Martindale    Page : 55,56   Edition : 37,


►  Contraindication : ischaemic heart disease, peripheral arterial disease, Cerebrovascular disease, hypertension, Hyperlipidaemia, Diabetes mellitus, inflammatory bowel disease, Moderate to severe hepatic impairment (NYHA class II to IV), renal impairment, hepatic impairment,
Ref :-   Book : Martindale    Page : 55   Edition : 37,
  ►  Mechanism of Action :   Etoricoxib is an NSAID reported to be a selective inhibitor of cyclo-oxygenase-2 (COX-2),
Ref :-   Book : Martindale    Page : 56   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with same pathway,

  ►  Pathway with its reference as follows :-
  • Inhibit COX-2 . --- (van Breemen, R., Tao, Y., & Li, W. (2011). Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia, 82(1), 38-43. http://dx.doi.org/10.1016/j.fitote.2010.09.004 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018740/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- SODIUM with Increase in Nutrient Level, POTASSIUM with Increase in Nutrient Level, LITHIUM with Increase in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GINKGO BILOBA with It causes Haemorrhage, apraxia, haematoma, hyphaema, permanent neurological deficit .,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Faecal, Renal,
    Ref :-   Book : Martindale    Page : 56   Edition : 37,


    ►    Plasma Half-life :   Min value :-   20 hours,    Max value :-   26 hours,
    Ref :-   Book : Goodman    Page : 965   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 56   Edition : 37,