Exemestane is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 789   Edition : 37,

  ►   Brandname : Aromasin

  ►  Strength : Tablet with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 788   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Advanced breast cancer, in postmenopausal women who are no longer responsive to anti-oestrogen therapy Oral 25 mg Tablet o.d. It is also used for adjuvant treatment of postmenopausal women with oestrogen-receptor positive early breast cancer, after 2 to 3 years of initial adjuvant tamoxifen treatment; a total of 5 years of adjuvant hormonal therapy should be given. In patients receiving potent inducers of the cytochrome P450 isoenzyme CYP3A4 (such as rifampicin or phenytoin), the recommended oral dose of exemestane is 50 mg once daily, after a meal.

Ref :-  Book : Martindale    Page : 788   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : gastrointestinal disturbance, anorexia, nausea, vomiting, diarrhoea, asthenia, hot flushes, Dizziness, drowsiness, headache, rash, hair thinning, vaginal dryness, vaginal bleeding, myalgia, arthralgia, bone fractures, insomnia, Depression, peripheral oedema, lymphoedema, increased cough, dyspnoea, hypertension, ,
Ref :-   Book : Martindale    Page : 744,788   Edition : 37,

►  Drug Interaction : Drug interaction of Exemestane is with ,  Rifampicin ,
Ref :-   Book : Martindale    Page : 788   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The metabolism of exemestane is mediated by the cytochrome P450 isoenzyme CYP3A4. Rifampicin, a potent inducer of CYP isoenzymes, can decrease plasma concentrations of exemestane. Use with other drugs that induce this isoenzyme may reduce the efficacy of exemestane. Exemestane should also be used cautiously with drugs that are substrates for CYP3A4 and that have a narrow therapeutic index. Significant effects on exemestane clearance by cytochrome P450 isoenzyme inhibitors are considered unlikely. Exemestane should not be given with oestrogen-containing drugs as these would negate its pharmacological action.,
Ref :-   Book : Martindale    Page : 788   Edition : 37,


►  Contraindication : premenopausal women (particularly in pregnancy),
Ref :-   Book : Martindale    Page : 744,788   Edition : 37,
  ►  Mechanism of Action :   Exemestane is a selective inhibitor of the aromatase (oestrogen synthase) system responsible for the conversion of androgens to oestrogen in peripheral tissues. It has a steroidal structure.,
Ref :-   Book : Martindale    Page : 788   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soyabean with Another pathway, Aesculus glabra with same pathway, Agaricus bisporus with same pathway, Agaricus blazei with same pathway, Onion with same pathway, Ginger (Zingiber officinale) with same pathway, Celery with same pathway, Celery with same pathway, Asparagus with same pathway, Tomato leaves with same pathway, Asparagus with same pathway, Green tea with same pathway, Dioon spinulosum i.e. gum plant with same pathway, Riedelia with same pathway, Coccothrinax with same pathway, Alpinia purpurata with same pathway, Red clove with same pathway, Apigenin with same pathway, Ayanin with same pathway, chrysin with same pathway, Fistein with same pathway, Fistein with same pathway, broussoflavonol F with same pathway, 3-hydroxyflavone with same pathway, Rutin with same pathway, robinetin with same pathway, Quercetin with same pathway, 7-hydroxyflavone with same pathway, 7-methoxyflavanone with same pathway, Humulus lupulus with same pathway, Dipteryx odorata with same pathway, Mulathi i.e licorice with same pathway, Urtica dioica with same pathway, Hesperetin with same pathway, anabasine with same pathway, berberine with same pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/ )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- (. J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/ )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Acetylcholistrase inhibitor --- (J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )
  • Aromatase inhibitor --- ( J Balunas M. Natural Products as Aromatase Inhibitors. Pubmed. 2008;8(6). )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level, POTASSIUM with Decrease in Nutrient Level, VITAMIN E with Decrease in Nutrient Level, N-ACETYLCYSTEINE with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MISTLETOE with Organ fibrosis and death, cardiotoxicity, bradycardia, hypovolaemic shock and CVD collapse, inflammatory reaction,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal, Fecal,
    Ref :-   Book : Martindale    Page : 788   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA