Ezetimibe is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1414   Edition : 37,

  ►   Brandname : Ezetib,Ezzicad,Imbibe,Vytorin,Inegy,Ezetrol

  ►  Strength : Tablet with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1413   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperlipidaemia Oral 10 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1414   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hyperlipidaemia Oral 10 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 481   Edition : 19,
►  Side Effect : headache, abdominal pain, diarrhea, gastrointestinal disorders, hypersensitivity reactions, rash, angioedema, fatigue, chest pain, arthralgia, ,
Ref :-   Book : Martindale    Page : 1413   Edition : 37,

►  Drug Interaction : Drug interaction of Ezetimibe is with Cyclosporine , Cholestyramine , Ropinirole ,
Ref :-   Book : Martindale    Page : 1414   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Colestyramine reduces the absorption of ezetimibe and should not be given at the same time of day. Ciclosporin has been reported to increase the plasma concentration of ezetimibe. An increased INR has been reported in patients given ezetimibe and oral anticoagulants. ,
Ref :-   Book : Martindale    Page : 414   Edition : 37,


►  Contraindication : Moderate or severe hepatic impairment,
Ref :-   Book : Martindale    Page : 1413   Edition : 37,
  ►  Mechanism of Action :   Decrease cholesterol transport form micelles into the enterocyte by inhibiting uptake through brush border protein NPC1L1→LDL decreases up to 20%, HDL increases ̴3%, triglyceride decrease ̴8%.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 330   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • Hypolipidemic effect. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1414   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   22 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1414   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,