Famciclovir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 979,980   Edition : 38,

  ►   Brandname : Famvir,Famtrex,Famirax,Ezovir,Fanle

  ►  Strength : Tablet with 125  mg, Tablet with 250  mg, Tablet with 500  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Herpes zoster infection Oral 500 mg Tablet t.i.d. Given for 7 days. And immunocompromised patients are given 500 mg three times daily for 10 days.
2 Herpes simplex infections Oral 250 mg Tablet t.i.d. Given for 5 days for first episodes of genital herpes; immunocompromised patients are given 500 mg twice daily for 7 days.
3 Recurrent episodes of genital herpes Oral 125 mg Tablet b.d. Given as an acute treatment for 5 days; Treatment should start in the prodromal period as soon as the first signs or symptoms appear. Immunocompromised patients are given 500 mg twice daily for 7 days.
4 Recurrent mucocutaneous herpes in HIV-infected patients Oral 500 mg Tablet b.d. Given as an acute treatment for 7 days.
5 Recurrent herpes labialis Oral 1.5 gm Tablet Given as a single dose, preferably begun in the prodromal period.

Ref :-  Book : Martindale    Page : 979   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute Mucocutaneous Infections by Herpes labialis Oral 1,500 mg Tablet o.d.
2 Genital Herpes Oral 1000 mg Tablet b.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1069   Edition : 19,
►  Side Effect : headache, nausea, abdominal pain and fever reported in immunocompromised patients, ,
Ref :-   Book : Martindale    Page : 967   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Famciclovir is with , ,  Probenecid ,
Ref :-   Book : Martindale    Page : 967   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  When given with famciclovir, probencid may reduce renal excretion of the active metabolite penciclovir, leading to increased plasma concentrations. The conversion of famciclovir to penciclovir is, in part, mediated by aldehyde oxidase, and strong inhibitors of this enzyme (such as raloxifene) may potentially reduce the formation of penciclovir.,
Ref :-   Book : Martindale    Page : 967   Edition : 37,


►  Contraindication : hypersensitivity to famciclovir or penciclovir,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 670   Edition : 3,
  ►  Mechanism of Action :   Famciclovir is a prodrug of the antiviral penciclovir. Famciclovir is phosphorylated by viral kinases and then inhibit viral DNA polymerase. ,
Ref :-   Book : Martindale    Page : 967   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 967   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 979   Edition : 38,