Famotidine is a Medicine belongs to Histamine H2-receptor antagonist group whose information about Brand can be referenced from   Book : Martindale    Page : 1843   Edition : 38,

  ►   Brandname : Acilo,Acipep,Pepcid,Ultra Heartburn Relief,Arfam,Famobeta,An Wei Te,Gaster

  ►  Strength : Tablet with 10  mg, Tablet with 20  mg, Suspension with 40  mg/5mL, Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1842   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Benign gastric ulceration Oral 40 mg h.s. Dose given daily up to 4 to 8 weeks. A dose of 20 mg twice daily has also been given.
2 Benign duodenal ulceration Oral 40 mg h.s. Dose given daily up to 4 to 8 weeks. A dose of 20 mg twice daily has also been given. A maintenance dose of 20 mg at bedtime may be given to prevent recurrence of duodenal ulceration.
3 Gastro-oesophageal reflux disease Oral 20 mg Tablet b.d. Above dose given for 6 to 12 weeks. Or dose up to 40 mg twice daily given if there is oesophageal ulceration. A maintenance dose of 20 mg twice daily may be given to prevent recurrence.
4 Heartburn Oral 10 mg Tablet Doses up to 10 mg twice daily is suggested.
5 Non-ulcer dyspepsia Oral 10 mg Tablet Doses up to 10 mg twice daily is suggested.
6 Zollinger-ellison syndrome Oral 20 mg q.i.d.
7 Prevention of Stress-related bleeding IV 20 mg Injection b.d. Ref Basic & Clinical Pharmacology, pg 1083, ed 12th.

Ref :-  Book : Martindale    Page : 1882   Edition : 37,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gastro-oesophageal reflux disease under 3 months Oral 500 micrograms/kg Oral Suspension o.d.
2 Gastro-oesophageal reflux disease 3 Month 1 Year Oral 500 micrograms/kg Suspension b.d.
3 Gastro-oesophageal reflux disease 1 Year 16 Year Oral 500 micrograms/kg Suspension b.d.
4 Gastro-oesophageal reflux disease 1 Year 16 Year IV 250 micrograms/kg Injection
5 Peptic ulcer 1 Year 16 Year Oral 500 micrograms/kg

Ref :- Book : Martindale    Page : 1842   Edition : 38,
►  Side Effect : diarrhea, Dizziness, myalgia, headache, arthralgia, constipation,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3,

►  Drug Interaction : Drug interaction of Famotidine is with NA

  ►    Mechanism of Drug Drug Interaction :  Unlike cimetidine famotidine does not inhibit cytochrome P450 isoenzymes, and therefore is considered to have little effect on the metabolism of other drugs by this route. However, like other H2-antagonists its effects on gastric pH may affect the absorption of some drugs whose absorption is dependent on an acid gastric pH.,
Ref :-   Book : Martindale    Page : 1842   Edition : 38,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3,
  ►  Mechanism of Action :   H 2 antagonists reduce acid secretion stimulated by histamine as well as by gastrin and cholinomimetic agents through two mechanisms. First, histamine released from ECL cells by gastrin or vagal stimulation is blocked from binding to the parietal cell H 2 receptor. Second, direct stimulation of the parietal cell by gastrin or acetylcholine has a diminished effect on acid secretion in the presence of H 2 -receptor blockade.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1084   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Banana with Another pathway, Pineapple with Another pathway, Lemon with Another pathway,

  ►  Pathway with its reference as follows :-
  • Gallic acid --- (Antiulcerogenic Effect of Gallic Acid in Rats and its Effect on Oxidant and Antioxidant Parameters in Stomach Tissue. (2013). Indian Journal Of Pharmacutical Sciences, 75(2). )
  • Gallic acid --- (Antiulcerogenic Effect of Gallic Acid in Rats and its Effect on Oxidant and Antioxidant Parameters in Stomach Tissue. (2013). Indian Journal Of Pharmacutical Sciences, 75(2). )
  • Gallic acid --- ( Antiulcerogenic Effect of Gallic Acid in Rats and its Effect on Oxidant and Antioxidant Parameters in Stomach Tissue. (2013). Indian Journal Of Pharmacutical Sciences, 75(2). )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757852/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, breast milk, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1881   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1881   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1881   Edition : 37,