Febuxostat is a Medicine belongs to Anti gout group whose information about Brand can be referenced from   Book :    Page :   Edition :    Martindale    Page : 607   Edition : 38  

  ►   Brandname : Febutaz, Adenuric, Uloric, Feburic
  ►  Strength : Tablet with 40 mg.  Tablet with 80 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 607   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperuricaemia associated with chronic gout Oral 40 mg Tablet o.d. If the serum uric acid is 6 mg per 100 ml or above after 2 weeks, the dose may be increased to 80 mg OD.

Ref :-  Book : Martindale    Page : 607   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Most common adverse effects are, Liver function abnormalities, Headache, Nausea, Diarrhea, Rashes, Hepatitis and gallstones have been reported, Less commonly reported effects are, Abdominal pain, Constipation, Fatigue, Oedema, Thirst, Hemiparesis, Guillain-Barré syndrome, Agitation, Depression, Flushing, Dizziness, Paraesthesia, Somnolence, Insomnia, Altered taste, Tinnitus, Vertigo, Hearing loss, Blurred Vision, Hypersenstivity, Electrolyte disturbances, Hyperglycaemia, Hyperlipidaemia, Diabetes mellitus, Renal failure, Nephrolithiasis, Herpes zoster infection, Urinary frequency, Dermatitis, Urticaria, Pruritus, Photosensitivity, Arthralgia, Myalgia, Anaemia, leucopenia, Thrombocytopenia, Also reported;, Myocardial infarction, Stroke, Arrhythmia, Angina, Hypotension, Hypertension, palpitations, And, Cough, Bronchitis, Dyspnoea, Upper respiratory-tract infections, Erectile dysfunction, Breast pain, Gynaecomastia, Hair discoloration, Alopecia
Ref :-   Book : Martindale    Page : 607   Edition : 38.  

►  Drug Interaction : Drug interaction of Febuxostat is with , ,  Mercaptopurine, Azathioprine , Theophylline
Ref :-   Book : Martindale    Page : 607   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Inhibition of Xanthine oxidase is known to increase concentrations of mercaptopurine or azathioprine, so use of febuxostat with these drugs is not recommended. Similarly caition is advised when febuxostat is given with theophylline. Febuxostat is metabolised via the uridine diphosphate glucuronosyltransferase enzyme system and inhibitors or inducers of this system might affect exposure to febuxostat. Serum uric acid should be monitered 1 to 2 weeks after starting treatment with a potent inducer of glucuronidation.
Ref :-   Book : Martindale    Page : 607   Edition : 38.  

►  Contraindication : During an acute attack of gout, Not recommended for the control of hyperuricemia secondary to malignant disease or cancer chemotherapy, Treatment in patients with ischaemic heart disease or congestive heart failure is not recommended
Ref :-   Book : Martindale    Page : 607   Edition : 38.  
  ►  Mechanism of Action :   Febuxostat is a non-purine, selective inhibitor of xanthine oxidase.
Ref :-   Book : Martindale    Page : 607   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Faecal, Renal
Ref :-   Book : Martindale    Page : 607   Edition : 38.  

►    Plasma Half-life :   Min value :-   Mean terminal t1/2 is 5 to 8 hrs,    Max value :-   NA
Ref :-   Book : Martindale    Page : 607   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA