Felbamate is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 523   Edition : 38,

  ►   Brandname : Felbatol,Taloxa

  ►  Strength : Tablet with 400  mg, Tablet with 600  mg, Suspension with 600  mg/5mL,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy Oral 1.2 3.6 gm Tablet When given as monotherapy; daily in 3 or 4 divided doses. The daily dose should be increased gradually under close supervision; increments of 600 mg every 2 weeks are given according to response, up to 2.4 g daily. Similar initial doses are given as adjunctive therapy, but the doses of the other antiepileptics should be decreased as necessary. This adjunctive dose may be increased by 1.2 g at weekly intervals, up to a maximum of 3.6 g. As with other antiepileptics, withdrawal of felbamate therapy or transition to or from another type of antiepileptic therapy should be made gradually to avoid precipitating an increase in the frequency of seizures.

Ref :-  Book : Martindale    Page : 522   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Lennox-Gastaut syndrome 2 Year 14 Year Oral 15 45 mg/kg Suspension

Ref :- Book : Martindale    Page : 522   Edition : 38,
►  Side Effect : anorexia, diplopia, Dizziness, headache, insomnia, nausea, rash, Somnolence, vomiting, weight loss, , reports of Stevens-Johnson syndrome,
Ref :-   Book : Martindale    Page : 523   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Felbamate is with ,  Gabapentin, Phenytoin , Phenobarbital , Carbamazapine ,
Ref :-   Book : Martindale    Page : 524   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy. The metabolism of felbamate is enhanced by enzyme inducerssuch as phenytoin, phenobarbital, or carbamazepine. In contrast, the half-life of felbamate may be prolonged by gabapentin. Felbamate inhibits or enhances the metabolism of several other antiepileptics and care is required when it is added to therapy.,
Ref :-   Book : Martindale    Page : 524   Edition : 37,


►  Contraindication : hepatic impairment, history of blood disorders, bone marrow depression,
Ref :-   Book : Martindale    Page : 524   Edition : 37,
  ►  Mechanism of Action :   Felbamate appears to have multiple mechanisms of action. It produces a use-dependent block of the NMDA receptor, with selectivity for the NR1-2B subtype. It also produces a barbiturate- like potentiation of GABA A receptor responses.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 412   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Radix notoginseng with same pathway, Rhizoma Acori with same pathway, Folium Gingko with same pathway, Radix Glycyrrhizae with same pathway, Onion with same pathway,

  ►  Pathway with its reference as follows :-
  • It block NMDA receptors . --- (Liang, W., & Lam, W. (2013). Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade, 6(8), 1039–1054. )
  • Rhizoma Acori --- ( Liang, W., & Lam, W. (2013). Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade, 6(8), 1039–1054. )
  • Folium Gingko --- (Liang, W., & Lam, W. (2013). Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade, 6(8), 1039–1054. )
  • NMDA receptor blocker . --- (Liang, W., & Lam, W. (2013). Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade, 6(8), 1039–1054. )
  • NMDA receptor blocker . --- (Johnston, G., & Chebib, M. (2009). Herbal Products and GABA Receptors. Encyclopedia Of Neuroscience, 4, 1095-1101. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817734/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306219/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, breast milk, Faecal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 524   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   16 hours,    Max value :-   23 hours,
    Ref :-   Book : Martindale    Page : 524   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 524   Edition : 37,